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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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MGAT5

Introduction

Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A is an enzyme that in humans is encoded by the MGAT5 gene.[1][2]

This gene encodes mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, a glycosyltransferase involved in the synthesis of protein-bound and lipid-bound oligosaccharides. Alterations of the oligosaccharides on cell surface glycoproteins cause significant changes in the adhesive or migratory behavior of a cell. Increase in the encoded protein’s activity may correlate with the progression of invasive malignancies.[2]

References

References

  1. ↑ Saito H, Nishikawa A, Gu J, Ihara Y, Soejima H, Wada Y, Sekiya C, Niikawa N, Taniguchi N (Feb 1994). “cDNA cloning and chromosomal mapping of human N-acetylglucosaminyltransferase V+”. Biochem Biophys Res Commun. 198 (1): 318–27. doi:10.1006/bbrc.1994.1045. PMID 8292036.
  2. ↑ 2.0 2.1 “Entrez Gene: MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase”.
Further reading

Further reading

  • Dennis JW, Granovsky M, Warren CE (2000). “Glycoprotein glycosylation and cancer progression”. Biochim. Biophys. Acta. 1473 (1): 21–34. doi:10.1016/s0304-4165(99)00167-1. PMID 10580127.
  • Buckhaults P, Chen L, Fregien N, Pierce M (1997). “Transcriptional regulation of N-acetylglucosaminyltransferase V by the src oncogene”. J. Biol. Chem. 272 (31): 19575–81. doi:10.1074/jbc.272.31.19575. PMID 9235963.
  • Park C, Jin UH, Lee YC, et al. (1999). “Characterization of UDP-N-acetylglucosamine:alpha-6-d-mannoside beta-1,6-N-acetylglucosaminyltransferase V from a human hepatoma cell line Hep3B”. Arch. Biochem. Biophys. 367 (2): 281–8. doi:10.1006/abbi.1999.1252. PMID 10395745.
  • Granovsky M, Fata J, Pawling J, et al. (2000). “Suppression of tumor growth and metastasis in Mgat5-deficient mice”. Nat. Med. 6 (3): 306–12. doi:10.1038/73163. PMID 10700233.
  • Ihara S, Miyoshi E, Ko JH, et al. (2002). “Prometastatic effect of N-acetylglucosaminyltransferase V is due to modification and stabilization of active matriptase by adding beta 1-6 GlcNAc branching”. J. Biol. Chem. 277 (19): 16960–7. doi:10.1074/jbc.M200673200. PMID 11864986.
  • Saito T, Miyoshi E, Sasai K, et al. (2002). “A secreted type of beta 1,6-N-acetylglucosaminyltransferase V (GnT-V) induces tumor angiogenesis without mediation of glycosylation: a novel function of GnT-V distinct from the original glycosyltransferase activity”. J. Biol. Chem. 277 (19): 17002–8. doi:10.1074/jbc.M200521200. PMID 11872751.
  • Dosaka-Akita H, Miyoshi E, Suzuki O, et al. (2004). “Expression of N-acetylglucosaminyltransferase v is associated with prognosis and histology in non-small cell lung cancers”. Clin. Cancer Res. 10 (5): 1773–9. doi:10.1158/1078-0432.CCR-1047-3. PMID 15014031.
  • Guo P, Zhang Y, Shen ZH, et al. (2004). “Effect of N-acetylglucosaminyltransferase V on the expressions of other glycosyltransferases”. FEBS Lett. 562 (1–3): 93–8. doi:10.1016/S0014-5793(04)00188-7. PMID 15044007.
  • Kim CH (2005). “Increased expression of N-acetylglucosaminyltransferase-V in human hepatoma cells by retinoic acid and 1alpha,25-dihydroxyvitamin D3”. Int. J. Biochem. Cell Biol. 36 (11): 2307–19. doi:10.1016/j.biocel.2004.04.021. PMID 15313475.
  • Tomiie M, Isaka S, Miyoshi E, et al. (2005). “Elevated expression of N-acetylglucosaminyltransferase V in first trimester human placenta”. Biochem. Biophys. Res. Commun. 330 (3): 999–1004. doi:10.1016/j.bbrc.2005.02.186. PMID 15809094.
  • Fang H, Huang W, Xu YY, et al. (2006). “Blocking of N-acetylglucosaminyltransferase V induces cellular endoplasmic reticulum stress in human hepatocarcinoma 7,721 cells”. Cell Res. 16 (1): 82–92. doi:10.1038/sj.cr.7310011. PMID 16467879.
  • Ishimura H, Takahashi T, Nakagawa H, et al. (2006). “N-acetylglucosaminyltransferase V and beta1-6 branching N-linked oligosaccharides are associated with good prognosis of patients with bladder cancer”. Clin. Cancer Res. 12 (8): 2506–11. doi:10.1158/1078-0432.CCR-05-1938. PMID 16638859.
  • Wang L, Liang Y, Li Z, et al. (2007). “Increase in beta1-6 GlcNAc branching caused by N-acetylglucosaminyltransferase V directs integrin beta1 stability in human hepatocellular carcinoma cell line SMMC-7721”. J. Cell. Biochem. 100 (1): 230–41. doi:10.1002/jcb.21071. PMID 16924681.
  • Li J, Wang XM, Wang Q, et al. (2007). “Down-regulation of N-acetylglucosaminyltransferase-V induces ER stress by changing glycosylation and function of GLUT1”. Arch. Biochem. Biophys. 463 (1): 102–9. doi:10.1016/j.abb.2007.03.005. PMID 17451637.
  • Kudo T, Nakagawa H, Takahashi M, et al. (2007). “N-glycan alterations are associated with drug resistance in human hepatocellular carcinoma”. Mol. Cancer. 6 (1): 32. doi:10.1186/1476-4598-6-32. PMC 1878497. PMID 17488527.