
Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
MIZF
Introduction
MBD2-interacting zinc finger, also known as MIZF, is a human gene.[1]
MIZF interacts with methyl-CpG-binding protein-2 (MBD2; MIM 603547), a component of the MeCP1 histone deacetylase (HDAC) complex, and plays a role in DNA methylation and transcription repression.[supplied by OMIM][1]
Further reading
Further reading
- Medina R, van der Deen M, Miele-Chamberland A; et al. (2007). “The HiNF-P/p220NPAT cell cycle signaling pathway controls nonhistone target genes”. Cancer Res. 67 (21): 10334–42. doi:10.1158/0008-5472.CAN-07-1560. PMID 17974976.
- Mitra P, Xie R, Harper JW; et al. (2007). “HiNF-P is a bifunctional regulator of cell cycle controlled histone H4 gene transcription”. J. Cell. Biochem. 101 (1): 181–91. doi:10.1002/jcb.21157. PMID 17163457.
- Fukushige S, Kondo E, Gu Z; et al. (2006). “RET finger protein enhances MBD2- and MBD4-dependent transcriptional repression”. Biochem. Biophys. Res. Commun. 351 (1): 85–92. doi:10.1016/j.bbrc.2006.10.005. PMID 17049487.
- Pulukuri SM, Rao JS (2006). “CpG island promoter methylation and silencing of 14-3-3sigma gene expression in LNCaP and Tramp-C1 prostate cancer cell lines is associated with methyl-CpG-binding protein MBD2”. Oncogene. 25 (33): 4559–72. doi:10.1038/sj.onc.1209462. PMID 16786000.
- Rual JF, Venkatesan K, Hao T; et al. (2005). “Towards a proteome-scale map of the human protein-protein interaction network”. Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Miele A, Braastad CD, Holmes WF; et al. (2005). “HiNF-P directly links the cyclin E/CDK2/p220NPAT pathway to histone H4 gene regulation at the G1/S phase cell cycle transition”. Mol. Cell. Biol. 25 (14): 6140–53. doi:10.1128/MCB.25.14.6140-6153.2005. PMID 15988025.
- Sekimata M, Homma Y (2005). “Regulation of Rb gene expression by an MBD2-interacting zinc finger protein MIZF during myogenic differentiation”. Biochem. Biophys. Res. Commun. 325 (3): 653–9. doi:10.1016/j.bbrc.2004.10.090. PMID 15541338.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Sekimata M, Homma Y (2004). “Sequence-specific transcriptional repression by an MBD2-interacting zinc finger protein MIZF”. Nucleic Acids Res. 32 (2): 590–7. doi:10.1093/nar/gkh249. PMID 14752047.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). “Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Mitra P, Xie RL, Medina R; et al. (2003). “Identification of HiNF-P, a key activator of cell cycle-controlled histone H4 genes at the onset of S phase”. Mol. Cell. Biol. 23 (22): 8110–23. PMID 14585971.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Sekimata M, Takahashi A, Murakami-Sekimata A, Homma Y (2001). “Involvement of a novel zinc finger protein, MIZF, in transcriptional repression by interacting with a methyl-CpG-binding protein, MBD2”. J. Biol. Chem. 276 (46): 42632–8. doi:10.1074/jbc.M107048200. PMID 11553631.
