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Health Dictionary

Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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MLL

Introduction

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Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila), also known as MLL, is a human gene.

MLL is a histone methyltransferase deemed a positive global regulator of gene transcription. This protein belongs to the group of histone-modifying enzymes and is involved in the epigenetic maintenance of transcriptional memory and the pathogenesis of human leukemias.[1] It also may participate in the process of GAD67 downregulation in schizophrenia.[2]

References

References

  1. ↑ Guenther MG, Jenner RG, Chevalier B, Nakamura T, Croce CM, Canaani E, Young RA (2005). “Global and Hox-specific roles for the MLL1 methyltransferase”. Proc. Natl. Acad. Sci. U.S.A. 102 (24): 8603–8. doi:10.1073/pnas.0503072102. PMID 15941828. free fulltext
  2. ↑ Huang HS, Matevossian A, Whittle C, Kim SY, Schumacher A, Baker SP, Akbarian S (2007). “Prefrontal dysfunction in schizophrenia involves mixed-lineage leukemia 1-regulated histone methylation at GABAergic gene promoters”. J. Neurosci. 27 (42): 11254–62. doi:10.1523/JNEUROSCI.3272-07.2007. PMID 17942719. commented at schizophreniaforum.org
Further reading

Further reading

  • Marschalek R, Nilson I, Löchner K; et al. (1998). “The structure of the human ALL-1/MLL/HRX gene”. Leuk. Lymphoma. 27 (5–6): 417–28. PMID 9477123.
  • Eguchi M, Eguchi-Ishimae M, Greaves M (2004). “The role of the MLL gene in infant leukemia”. Int. J. Hematol. 78 (5): 390–401. PMID 14704031.
  • Daser A, Rabbitts TH (2004). “Extending the repertoire of the mixed-lineage leukemia gene MLL in leukemogenesis”. Genes Dev. 18 (9): 965–74. doi:10.1101/gad.1195504. PMID 15132992.
  • Li ZY, Liu DP, Liang CC (2005). “New insight into the molecular mechanisms of MLL-associated leukemia”. Leukemia. 19 (2): 183–90. doi:10.1038/sj.leu.2403602. PMID 15618964.
  • Douet-Guilbert N, Morel F, Le Bris MJ; et al. (2005). “Rearrangement of MLL in a patient with congenital acute monoblastic leukemia and granulocytic sarcoma associated with a t(1;11)(p36;q23) translocation”. Leuk. Lymphoma. 46 (1): 143–6. doi:10.1080/104281904000010783. PMID 15621793.
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