Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
MOAP1
Introduction
Modulator of apoptosis 1 is a protein that in humans is encoded by the MOAP1 gene.[1][2]
The protein encoded by this gene was identified by its interaction with apoptosis regulator BAX protein. This protein contains a Bcl-2 homology 3 (BH3)-like motif, which is required for the association with BAX. When overexpressed, this gene has been shown to mediate caspase-dependent apoptosis.[2]
References
References
- ↑ Tan KO, Tan KM, Chan SL, Yee KS, Bevort M, Ang KC, Yu VC (May 2001). “MAP-1, a novel proapoptotic protein containing a BH3-like motif that associates with Bax through its Bcl-2 homology domains”. J Biol Chem. 276 (4): 2802–7. doi:10.1074/jbc.M008955200. PMID 11060313.
- ↑ 2.0 2.1 “Entrez Gene: MOAP1 modulator of apoptosis 1”.
Further reading
Further reading
- Hartley JL, Temple GF, Brasch MA (2001). “DNA cloning using in vitro site-specific recombination”. Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
- Simpson JC, Wellenreuther R, Poustka A, et al. (2001). “Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing”. EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). “Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Wiemann S, Arlt D, Huber W, et al. (2004). “From ORFeome to biology: a functional genomics pipeline”. Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
- Baksh S, Tommasi S, Fenton S, et al. (2005). “The tumor suppressor RASSF1A and MAP-1 link death receptor signaling to Bax conformational change and cell death”. Mol. Cell. 18 (6): 637–50. doi:10.1016/j.molcel.2005.05.010. PMID 15949439.
- Rual JF, Venkatesan K, Hao T, et al. (2005). “Towards a proteome-scale map of the human protein-protein interaction network”. Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Vos MD, Dallol A, Eckfeld K, et al. (2006). “The RASSF1A tumor suppressor activates Bax via MOAP-1”. J. Biol. Chem. 281 (8): 4557–63. doi:10.1074/jbc.M512128200. PMID 16344548.
- Mehrle A, Rosenfelder H, Schupp I, et al. (2006). “The LIFEdb database in 2006”. Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
- Lim J, Hao T, Shaw C, et al. (2006). “A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration”. Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
- Fu NY, Sukumaran SK, Yu VC (2007). “Inhibition of ubiquitin-mediated degradation of MOAP-1 by apoptotic stimuli promotes Bax function in mitochondria”. Proc. Natl. Acad. Sci. U.S.A. 104 (24): 10051–6. doi:10.1073/pnas.0700007104. PMC 1877986. PMID 17535899.