
Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
MYH4
Introduction
Myosin-4 also known as myosin, heavy chain 4 is a protein which in humans is encoded by the MYH4 gene.[1]
Function
Function
MYH4 is a gene that encodes a sarcomeric myosin.
References
References
- ↑ Edwards YH, Parkar M, Povey S, West LF, Parrington JM, Solomon E (May 1985). “Human myosin heavy chain genes assigned to chromosome 17 using a human cDNA clone as probe”. Ann. Hum. Genet. 49 (Pt 2): 101–9. doi:10.1111/j.1469-1809.1985.tb01681.x. PMID 3000272.
Further reading
Further reading
- Sant’ana Pereira JA, Wessels A, Nijtmans L, et al. (1995). “New method for the accurate characterization of single human skeletal muscle fibres demonstrates a relation between mATPase and MyHC expression in pure and hybrid fibre types”. J. Muscle Res. Cell. Motil. 16 (1): 21–34. doi:10.1007/BF00125307. PMID 7751402.
- Weiss A, McDonough D, Wertman B, et al. (1999). “Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved”. Proc. Natl. Acad. Sci. U.S.A. 96 (6): 2958–63. doi:10.1073/pnas.96.6.2958. PMC 15877. PMID 10077619.
- Barton PJ, Buckingham ME (1985). “The myosin alkali light chain proteins and their genes”. Biochem. J. 231 (2): 249–61. PMC 1152739. PMID 3904738.
- Horton MJ, Brandon CA, Morris TJ, et al. (2001). “Abundant expression of myosin heavy-chain IIB RNA in a subset of human masseter muscle fibres”. Arch. Oral Biol. 46 (11): 1039–50. doi:10.1016/S0003-9969(01)00066-8. PMC 3848045. PMID 11543711.
- Weiss A, Schiaffino S, Leinwand LA (1999). “Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity”. J. Mol. Biol. 290 (1): 61–75. doi:10.1006/jmbi.1999.2865. PMID 10388558.
- Larsson L, Moss RL (1993). “Maximum velocity of shortening in relation to myosin isoform composition in single fibres from human skeletal muscles”. J. Physiol. 472: 595–614. doi:10.1113/jphysiol.1993.sp019964. PMC 1160504. PMID 8145163.
- Li ZH, Spektor A, Varlamova O, Bresnick AR (2003). “Mts1 regulates the assembly of nonmuscle myosin-IIA”. Biochemistry. 42 (48): 14258–66. doi:10.1021/bi0354379. PMID 14640694.
- Sowa ME, Bennett EJ, Gygi SP, Harper JW (2009). “Defining the human deubiquitinating enzyme interaction landscape”. Cell. 138 (2): 389–403. doi:10.1016/j.cell.2009.04.042. PMC 2716422. PMID 19615732.
- Ford HL, Silver DL, Kachar B, et al. (1997). “Effect of Mts1 on the structure and activity of nonmuscle myosin II”. Biochemistry. 36 (51): 16321–7. doi:10.1021/bi971182l. PMID 9405067.
- Soussi-Yanicostas N, Whalen RG, Petit C (1993). “Five skeletal myosin heavy chain genes are organized as a multigene complex in the human genome”. Hum. Mol. Genet. 2 (5): 563–9. doi:10.1093/hmg/2.5.563. PMID 8518795.
- Ewing RM, Chu P, Elisma F, et al. (2007). “Large-scale mapping of human protein-protein interactions by mass spectrometry”. Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMCÂ 1847948. PMIDÂ 17353931.
