MYLK4

Myosin light chain kinase 4 also known as MYLK4 is an enzyme which in humans is encoded by the MYLK2 gene.^[2] MYLK4 is a member of the myosin light-chain kinase family of serine/threonine-specific protein kinases that phosphorylate the regulatory light chain of myosin II.^[3]

This protein acts as an enzyme that catalyzes the following reaction: ATP + a protein -> ADP + a phosphoprotein.^[4]

MYLK4 is also involved in protein amino acid phosphorylation meaning that it adds a phosphate group onto the molecule.^[5]

Not very much is known about the specific functional characteristics of MLYK4, but it has recently been found that the gene may possibly have a role in having at least one driver mutation for cancer.^{_Human_Myosin_Light_Chain_Kinase_Family_Member_4_(LOC340156)_PDB_Code:_2X4F-6|[6]} MYLK4 may also be involved in transferase activity, ATP binding, protein serine/threonine kinase activity, and also nucleotide binding.^{_MYLK4_Protein_|_MYLK4_Antibody-7|[7]} Other names for MYLK4 are CaMLCK like; EG238564; MYLK4; Mylk4; Myosin light chain kinase family, member 4; SgK085; SGK085; Sgk085; Sugen kinase 85; Uncharacterized serine/threonine-protein kinase SgK085.^[8]

There are other known myosin light-chain kinase enzymes.

References

↑ “RCSB Protein Data Bank – Structure Summary for 2X4F – The Crystal Structure of the Human Myosin Light Chain Kinase Loc340156”.
↑ Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S (December 2002). “The protein kinase complement of the human genome”. Science. 298 (5600): 1912–34. doi:10.1126/science.1075762. PMID 12471243.
↑ Gao Y, Ye LH, Kishi H, Okagaki T, Samizo K, Nakamura A, Kohama K (June 2001). “Myosin light chain kinase as a multifunctional regulatory protein of smooth muscle contraction”. IUBMB Life. 51 (6): 337–44. doi:10.1080/152165401753366087. PMID 11758800.
↑ “MYLK4 – Protein (Function), MYLK4 – Protein (Function)”.
↑ “www.phosphosite.org”.
_Human_Myosin_Light_Chain_Kinase_Family_Member_4_(LOC340156)_PDB_Code:_2X4F_6-0|↑ “SGC | Human Myosin Light Chain Kinase Family Member 4 (LOC340156) PDB Code: 2X4F”.
_MYLK4_Protein_|_MYLK4_Antibody_7-0|↑ “MYLK4 Gene – GeneCards | MYLK4 Protein | MYLK4 Antibody”.
↑ “Sgk085 : Protein Overview : UCSD Molecule Pages”.

[2X4F-1] “RCSB Protein Data Bank – Structure Summary for 2X4F – The Crystal Structure of the Human Myosin Light Chain Kinase Loc340156”.

[pmid12471243-2] Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S (December 2002). “The protein kinase complement of the human genome”. Science. 298 (5600): 1912–34. doi:10.1126/science.1075762. PMID 12471243.

[pmid11758800-3] Gao Y, Ye LH, Kishi H, Okagaki T, Samizo K, Nakamura A, Kohama K (June 2001). “Myosin light chain kinase as a multifunctional regulatory protein of smooth muscle contraction”. IUBMB Life. 51 (6): 337–44. doi:10.1080/152165401753366087. PMID 11758800.

[urlMYLK4_-_Protein_(Function),_MYLK4_-_Protein_(Function)-4] “MYLK4 – Protein (Function), MYLK4 – Protein (Function)”.

[urlwww.phosphosite.org-5] “www.phosphosite.org”.

[urlSGC_|_Human_Myosin_Light_Chain_Kinase_Family_Member_4_(LOC340156)_PDB_Code:_2X4F-6] _Human_Myosin_Light_Chain_Kinase_Family_Member_4_(LOC340156)_PDB_Code:_2X4F_6-0|↑ “SGC | Human Myosin Light Chain Kinase Family Member 4 (LOC340156) PDB Code: 2X4F”.

[urlMYLK4_Gene_-_GeneCards_|_MYLK4_Protein_|_MYLK4_Antibody-7] _MYLK4_Protein_|_MYLK4_Antibody_7-0|↑ “MYLK4 Gene – GeneCards | MYLK4 Protein | MYLK4 Antibody”.

[urlSgk085_:_Protein_Overview_:_UCSD_Molecule_Pages-8] “Sgk085 : Protein Overview : UCSD Molecule Pages”.

[2]

[3]

[4]

[5]

_Human_Myosin_Light_Chain_Kinase_Family_Member_4_(LOC340156)_PDB_Code:_2X4F-6|[6]

_MYLK4_Protein_|_MYLK4_Antibody-7|[7]

[8]

MYLK4

References

Looking for the patient version?