Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Macrocytic anemia historical perspective
Introduction
Overview
Overview
Megaloblastic anemia and pernicious anemia was first discovered by Osler and Gardner in 1877 at Montreal. Increase in bone marrow cells was noted by Cohnheim in 1876.
Historical Perspective
Historical Perspective
Discovery
Following facts were found in historical perspective:[1]
- Megaloblastic anemia and pernicious anemia was first discovered by Osler and Gardner in 1877 at Montreal.
- Increase in bone marrow cells was noted by Cohnheim in 1876.
- The association between megaloblastic(pernicious) anemia and spinal cord lesions was made in 1887 by Lichtheim.
- Subacute combined degeneration of spinal cord was coined by Russell et al in 1900.
- In 1908, Cabot was the first to discover the association between megaloblastic anemia and the development of numbness and tingling of extremities.
- In 1923, Minot and Murphy started a diet for people with anemia which had animal sources like liver, muscle meat, leafy vegetables, eggs and milk. they discovered rises in cell count and hemoglobin levels.
- In 1934, Whipple, Minot and Murphy were awarded with Nobel prize for medicine and physiology for saving the lives of anemic people with dietary measures.
References
References
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Amandeep Singh M.D.[2] Omer Kamal, M.D.[3]