Developer site: The content shown here is test data.

MyEClinic
MyEClinic
Health Dictionary AI Health Chat Find an Online Doctor
A serene Zen garden with raked sand and smooth stones, symbolising clarity and calm

Health Dictionary

Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

Back to skin conditions

Macrophage-capping protein

Introduction

Macrophage-capping protein (CAPG) also known as actin regulatory protein CAP-G is a protein that in humans is encoded by the CAPG gene.[1][2][3]

Function

Function

This gene encodes a member of the gelsolin/villin family of actin-regulatory proteins.[4] The encoded protein reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner, but does not sever preformed actin filaments. By capping the barbed ends of actin filaments, the encoded protein contributes to the control of actin-based motility in non-muscle cells. Alternatively spliced transcript variants have been observed, but have not been fully described.[3]

References

References

  1. ↑ Dabiri GA, Young CL, Rosenbloom J, Southwick FS (Sep 1992). “Molecular cloning of human macrophage capping protein cDNA. A unique member of the gelsolin/villin family expressed primarily in macrophages”. J Biol Chem. 267 (23): 16545–52. PMID 1322908.
  2. ↑ Pellieux C, Desgeorges A, Pigeon CH, Chambaz C, Yin H, Hayoz D, Silacci P (Jul 2003). “Cap G, a gelsolin family protein modulating protective effects of unidirectional shear stress”. J Biol Chem. 278 (31): 29136–44. doi:10.1074/jbc.M300598200. PMID 12754261.
  3. ↑ 3.0 3.1 “Entrez Gene: CAPG capping protein (actin filament), gelsolin-like”.
  4. ↑ Ghoshdastider, U; Popp, D; Burtnick, L. D.; Robinson, R. C. (2013). “The expanding superfamily of gelsolin homology domain proteins”. Cytoskeleton. 70 (11): 775–95. doi:10.1002/cm.21149. PMID 24155256.
Further reading

Further reading

  • Southwick FS (1995). “Gain-of-function mutations conferring actin-severing activity to human macrophage cap G”. J. Biol. Chem. 270 (1): 45–8. doi:10.1074/jbc.270.1.45. PMID 7814409.
  • Mishra VS, Henske EP, Kwiatkowski DJ, Southwick FS (1995). “The human actin-regulatory protein cap G: gene structure and chromosome location”. Genomics. 23 (3): 560–5. doi:10.1006/geno.1994.1543. PMID 7851883.
  • Maruyama K, Sugano S (1994). “Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides”. Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Hirano T, Kobayashi R, Hirano M (1997). “Condensins, chromosome condensation protein complexes containing XCAP-C, XCAP-E and a Xenopus homolog of the Drosophila Barren protein”. Cell. 89 (4): 511–21. doi:10.1016/S0092-8674(00)80233-0. PMID 9160743.
  • Cabello OA, Eliseeva E, He WG, et al. (2002). “Cell cycle-dependent expression and nucleolar localization of hCAP-H”. Mol. Biol. Cell. 12 (11): 3527–37. doi:10.1091/mbc.12.11.3527. PMC 60273. PMID 11694586.
  • Van Impe K, De Corte V, Eichinger L, et al. (2003). “The Nucleo-cytoplasmic actin-binding protein CapG lacks a nuclear export sequence present in structurally related proteins”. J. Biol. Chem. 278 (20): 17945–52. doi:10.1074/jbc.M209946200. PMID 12637565.
  • De Corte V, Van Impe K, Bruyneel E, et al. (2005). “Increased importin-beta-dependent nuclear import of the actin modulating protein CapG promotes cell invasion”. J. Cell Sci. 117 (Pt 22): 5283–92. doi:10.1242/jcs.01410. PMID 15454578.
  • Watari A, Takaki K, Higashiyama S, et al. (2007). “Suppression of tumorigenicity, but not anchorage independence, of human cancer cells by new candidate tumor suppressor gene CapG”. Oncogene. 25 (56): 7373–80. doi:10.1038/sj.onc.1209732. PMID 16767159.
  • Chi A, Valencia JC, Hu ZZ, et al. (2007). “Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes”. J. Proteome Res. 5 (11): 3135–44. doi:10.1021/pr060363j. PMID 17081065.