Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Major depressive disorder laboratory findings
Introduction
Overview
Overview
There are no diagnostic laboratory findings associated with major depressive disorder.
Laboratory Findings
Laboratory Findings
- There are no diagnostic laboratory findings associated with major depressive disorder. [1]
- Dexamethasone suppression test: [2]
- About 50% of patients with major depressive disorder have abnormal dexamethasone suppression test. Nonsuppression (positive test result) shows cortisol hypersecretion secondary to a hyperactive hypothalamus-pituitary-adrenal axis.
- However, dexamethasone suppression test is not routinely used in the diagnosis of major depressive disorders due to high rates of false positives and false negatives.
- Diminished TSH in response to TRH and decreased prolactin release in response to tryptophan have been reported in patients with major depression. However, the results are not definitive, and thus, are not used routinely used in clinical practice.
References
References
- ↑ Boland, Robert (2022). Kaplan & Sadock’s synopsis of psychiatry. Philadelphia: Wolters Kluwer. ISBN 1975145569.
- ↑ Boland, Robert (2022). Kaplan & Sadock’s synopsis of psychiatry. Philadelphia: Wolters Kluwer. ISBN 1975145569.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Mitra Chitsazan, M.D.[2]