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Major histocompatibility complex, class I-related

Introduction

Major histocompatibility complex class I-related gene protein is a protein that in humans is encoded by the MR1 gene.[1][2][3] Human MR1 protein has 341 amino acid residues with a molecular weight of 39 366.[4] The MR1 protein is able to bind to molecules derived from bacterial riboflavin biosynthesis, and then present it to mucosal associated invariant T cells for activation.[5][6] Within cells, MR1 is mostly stored inside the endoplasmic reticulum, where the binding of bacterial riboflavin-related molecules to MR1 occurs, causing it to be sent to the cell surface for presentation.[7]

References

References

  1. ↑ Hashimoto K, Hirai M, Kurosawa Y (August 1995). “A gene outside the human MHC related to classical HLA class I genes”. Science. 269 (5224): 693–5. doi:10.1126/science.7624800. PMID 7624800.
  2. ↑ Yamaguchi H, Kurosawa Y, Hashimoto K (September 1998). “Expanded genomic organization of conserved mammalian MHC class I-related genes, human MR1 and its murine ortholog”. Biochemical and Biophysical Research Communications. 250 (3): 558–64. doi:10.1006/bbrc.1998.9353. PMID 9784382.
  3. ↑ “Entrez Gene: MR1 major histocompatibility complex, class I-related”.
  4. ↑ “UniProt, Q95460”.
  5. ↑ Corbett AJ, Eckle SB, Birkinshaw RW, Liu L, Patel O, Mahony J, Chen Z, Reantragoon R, Meehan B, Cao H, Williamson NA, Strugnell RA, Van Sinderen D, Mak JY, Fairlie DP, Kjer-Nielsen L, Rossjohn J, McCluskey J (May 2014). “T-cell activation by transitory neo-antigens derived from distinct microbial pathways”. Nature. 509 (7500): 361–5. doi:10.1038/nature13160. PMID 24695216.
  6. ↑ Kjer-Nielsen L, Patel O, Corbett AJ, Le Nours J, Meehan B, Liu L, Bhati M, Chen Z, Kostenko L, Reantragoon R, Williamson NA, Purcell AW, Dudek NL, McConville MJ, O’Hair RA, Khairallah GN, Godfrey DI, Fairlie DP, Rossjohn J, McCluskey J (November 2012). “MR1 presents microbial vitamin B metabolites to MAIT cells”. Nature. 491 (7426): 717–23. doi:10.1038/nature11605. PMID 23051753.
  7. ↑ McWilliam HE, Eckle SB, Theodossis A, Liu L, Chen Z, Wubben JM, Fairlie DP, Strugnell RA, Mintern JD, McCluskey J, Rossjohn J, Villadangos JA (May 2016). “The intracellular pathway for the presentation of vitamin B-related antigens by the antigen-presenting molecule MR1”. Nature Immunology. 17 (5): 531–7. doi:10.1038/ni.3416. PMID 27043408.
Further reading

Further reading

  • Maruyama K, Sugano S (January 1994). “Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides”. Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Yamaguchi H, Hirai M, Kurosawa Y, Hashimoto K (September 1997). “A highly conserved major histocompatibility complex class I-related gene in mammals”. Biochemical and Biophysical Research Communications. 238 (3): 697–702. doi:10.1006/bbrc.1997.7379. PMID 9325151.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). “Construction and characterization of a full length-enriched and a 5′-end-enriched cDNA library”. Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Riegert P, Wanner V, Bahram S (October 1998). “Genomics, isoforms, expression, and phylogeny of the MHC class I-related MR1 gene”. Journal of Immunology. 161 (8): 4066–77. PMID 9780177.
  • Parra-Cuadrado JF, Navarro P, Mirones I, Setién F, Oteo M, Martínez-Naves E (August 2000). “A study on the polymorphism of human MHC class I-related MR1 gene and identification of an MR1-like pseudogene”. Tissue Antigens. 56 (2): 170–2. doi:10.1034/j.1399-0039.2000.560211.x. PMID 11019920.
  • Miley MJ, Truscott SM, Yu YY, Gilfillan S, Fremont DH, Hansen TH, Lybarger L (June 2003). “Biochemical features of the MHC-related protein 1 consistent with an immunological function”. Journal of Immunology. 170 (12): 6090–8. doi:10.4049/jimmunol.170.12.6090. PMID 12794138.
  • Hempelmann A, Kumar S, Muralitharan S, Sander T (July 2006). “Myofibrillogenesis regulator 1 gene (MR-1) mutation in an Omani family with paroxysmal nonkinesigenic dyskinesia”. Neuroscience Letters. 402 (1–2): 118–20. doi:10.1016/j.neulet.2006.03.048. PMID 16632198.