Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Malignant peripheral nerve sheath tumor causes
Introduction
Overview
Overview
Malignant peripheral nerve sheath tumor may be caused by a mutation in the neurofibromatosis type I gene.[1][2]
Causes
Causes
- Malignant peripheral nerve sheath tumor may be caused by a mutation in the neurofibromatosis type I gene.[1][2]
- About half of the cases of malignant peripheral nerve sheath tumor (MPNST) occur along with NF1. The lifetime risk of having both of these conditions is at 8–13% while those with only MPNST have a 0.001% in the general population.[2]
- The NF1 gene locus is on chromosome 17q11.2 and the gene product is neurofibromin, which acts as a tumor suppressor. Inactivation of the gene predisposes to tumor development.[1]
References
References
- ↑ 1.0 1.1 1.2 Albright, A (2008). Principles and practice of pediatric neurosurgery. New York: Thieme. ISBN 1588903958.
- ↑ 2.0 2.1 2.2 Ferrari, Andrea; Gianni Bisogno; Modesto Carli (2007). “Management Of Childhood Malignant Peripheral Nerve Sheath Tumor”. Pediatric Drugs. 9 (4): 239–48. doi:10.2165/00148581-200709040-00005. PMID 17705563.
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Marjan Khan M.B.B.S.[2]