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Health Dictionary

Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Mallory-Weiss syndrome pathophysiology

Introduction

Overview

Overview

The exact pathogenesis of Mallory-Weiss syndrome is not fully understood. It is thought that Mallory-Weiss syndrome is the result of sudden increase in intraabdominal pressure that causes mucosal lacerations.

Pathogenesis

Pathogenesis

  • The exact pathogenesis of Mallory-Weiss syndrome is not fully understood.
  • It is thought that Mallory-Weiss syndrome is the result of sudden increase in intraabdominal pressure that causes mucosal lacerations. If the tear involves the esophageal venous or arterial Plexus,bleeding occurs.[1][2]
Genetics

Genetics

There are no genes involved in the pathogenesis of Mallory-Weiss syndrome.

Gross Pathology

Gross Pathology

On gross pathology, Mallory-Weiss tears may appear red longitudinal break in the mucosa, sometimes may extend into muscularis mucosa, and covered by a clot. Active bleeding may also be observed.

References

References

  1. ↑ Byrne, John J.; Moran, John M. (1965). “The Mallory-Weiss Syndrome”. New England Journal of Medicine. 272 (8): 398–400. doi:10.1056/NEJM196502252720805. ISSN 0028-4793.
  2. ↑ Decker, John P.; Zamcheck, Norman; Mallory, G. Kenneth (1953). “Mallory-Weiss Syndrome”. New England Journal of Medicine. 249 (24): 957–963. doi:10.1056/NEJM195312102492401. ISSN 0028-4793.


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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamed Diab, MD [2]