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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Mallory-Weiss syndrome risk factors

Introduction

Overview

Overview

The most potent risk factors in the development of Mallory-Weiss syndrome are Alcohol use and Hiatal hernia. The less potent risk factor in the development of Mallory-Weiss syndrome is age.

Common Risk Factors

Common Risk Factors

  • Alcohol use: 40% to 80% of patients with Mallory-Weiss syndrome has a history of heavy alcohol use which lead to vomiting.[1][2][3][4][5]
  • Hiatal hernia: It is still unclear if it is a risk factor or not. It is reported in 40% to 80% of patients with Mallory-Weiss syndrome but big case-control study found no big difference in prevalence of hiatal

hernia between patients with Mallory-Weiss syndrome and controls.[2][6]

Less Common Risk Factors

Less Common Risk Factors

  • Age: Mallory-Weiss syndrome is suggested to be associated with increased age.[7] However, most tears happen in patients younger than 40, which suggests that age doesn’t have a major role. Mallory-Weiss syndrome was also reported in infants. [8]
References

References

  1. ↑ Michel L, Serrano A, Malt RA (1980). “Mallory-Weiss syndrome. Evolution of diagnostic and therapeutic patterns over two decades”. Ann. Surg. 192 (6): 716–21. PMC 1344969. PMID 7447523.
  2. ↑ 2.0 2.1 Dagradi AE, Broderick JT, Juler G, Wolinsky S, Stempien SJ (1966). “The Mallory-Weiss syndrome and lesion. A study of 30 cases”. Am J Dig Dis. 11 (9): 710–21. PMID 5946360.
  3. ↑ Harris JM, DiPalma JA (1993). “Clinical significance of Mallory-Weiss tears”. Am. J. Gastroenterol. 88 (12): 2056–8. PMID 8249973.
  4. ↑ Knauer CM (1976). “Mallory-Weiss syndrome. Characterization of 75 Mallory-weiss lacerations in 528 patients with upper gastrointestinal hemorrhage”. Gastroenterology. 71 (1): 5–8. PMID 1084311.
  5. ↑ Sugawa C, Benishek D, Walt AJ (1983). “Mallory-Weiss syndrome. A study of 224 patients”. Am. J. Surg. 145 (1): 30–3. PMID 6600377.
  6. ↑ Corral JE, Keihanian T, Kröner PT, Dauer R, Lukens FJ, Sussman DA (2017). “Mallory Weiss syndrome is not associated with hiatal hernia: a matched case-control study”. Scand. J. Gastroenterol. 52 (4): 462–464. doi:10.1080/00365521.2016.1267793. PMID 28007004.
  7. ↑ Penston JG, Boyd EJ, Wormsley KG (1992). “Mallory-Weiss tears occurring during endoscopy: a report of seven cases”. Endoscopy. 24 (4): 262–5. doi:10.1055/s-2007-1009122. PMID 1366134.
  8. ↑ Cannon RA, Lee G, Cox KL (1985). “Gastrointestinal hemorrhage due to Mallory-Weiss syndrome in an infant”. J. Pediatr. Gastroenterol. Nutr. 4 (2): 323–4. PMID 3872935.


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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamed Diab, MD [2]