Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Manchester score
Introduction
Overview
Overview
Manchester score is an indicator of prognosis in small cell lung cancer.[1][2] It is calculated from a number of physical and biochemical markers.
A patient with small cell lung cancer scores one point for each of the following: –
- Serum lactate dehydrogenase exceeds the upper limit of the reference range.
- Serum sodium concentration less than 132 mmol/l.
- Serum alkaline phosphatase over one-and-a-half times the upper limit of the reference range.
- Serum bicarbonate less than 24.
- Karnofsky performance status less than 60.
- Extensive stage disease.
Prognosis
Prognosis
| Manchester score | Prognostic group | Two year survival (%) |
|---|---|---|
| 0-1 | Good | 16.2 |
| 2-3 | Medium | 2.5 |
| 4 or more | Poor | 0 |
References
References
- ↑ Cerny, T (1987). “Pretreatment prognostic factors and scoring system in 407 small-cell lung cancer patients”. International Journal of Cancer. 39 (2): 146–149. Unknown parameter
|coauthors=ignored (help) - ↑ Kawahara, Masaaki (1996). “Prognostic factors and prognostic staging system for small cell lung cancer”. Japanese Journal of Clinical Oncology. Oxford University Press. 27 (3): 158–165. ISSN: 0368-2811. Unknown parameter
|coauthors=ignored (help) - ↑ Maestu, I (Jun 1997). “Pretreatment prognostic factors for survival in small-cell lung cancer: a new prognostic index and validation of three known prognostic indices on 341 patients”. Annals of Oncology. 8 (6): 547–553. Unknown parameter
|coauthors=ignored (help)
Editor-In-Chief:
C. Michael Gibson, M.S., M.D. [1]