Health Dictionary
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Mannose
Introduction
Mannose is a sugar monomer of the hexose series of carbohydrates.
Metabolism
Metabolism
Mannose enters the carbohydrate metabolism stream in two steps:
- First it undergoes phosphorylation to mannose-6-phosphate by hexokinase.
- Then, it is converted to fructose-6-phosphate by mannose phosphate isomerase.
Formation
Formation
Mannose can be formed by the oxidation of mannitol.
It can also be formed from D-glucose in the Lobry-de Bruyn-van Ekenstein transformation
Etymology
Etymology
The root of both “mannose” and “manitol” is manna, which the Bible records as the food supplied to the Israelites during their journey through the Sinai Peninsula. Manna is a sweet secretion of several trees and shrubs, such as Fraxinus ornus.
Cranberry juice
Cranberry juice
D-Mannose, which appears in some fruits including cranberry, has been shown to prevent the adhesion of bacteria to tissues of the urinary tract and bladder.
Configuration
Configuration
The fact that D-mannose has the same configuration at its penultimate carbon as D–glyceraldehyde is unsurprising as that is what defines the dextro classification. However, mannose differs from D-glucose by inversion of the C2 chiral centre. This apparently simple change leads to the drastically different chemistry of the two hexoses, as it does the remaining six hexoses.
Mnemonic
Mnemonic
The hexoses can be remembered conveniently by the following phrase: