Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Mantle cell lymphoma causes
Introduction
Overview
Overview
The causes of mantle cell lymphoma have not been clearly identified.
Causes
Causes
- Mantle cell lymphoma is thought to be caused when the somatic cells acquire non-inherited genetic mutations.
- The typical mutation occurring in mantle cell lymphoma due to the “reciprocal translocation” between chromosome 11 and chromosome 14 t(11;14) causes the over expression of cyclin D1 which results in uncontrolled growth of B cells leading to lymphoma development.
- However, the initiating factors of these genetic alterations are generally not identifiable. People with no particular risk factors for lymphoma development are commonly affected by these alterations.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ali Akram, M.B.B.S.[2] Sowminya Arikapudi, M.B,B.S. [3]