Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Marantic endocarditis
Introduction
Marantic endocarditis, also known as non-bacterial thrombotic endocarditis (NBTE), is the deposition of small sterile vegetations on valve leaflets. Marantic vegetations are often associated with previous rheumatic fever. Other risk factors include:
- hypercoagulable states,
- mucin-producing adenocarcinomas,
- lupus and
- trauma (e.g., catheters).
The disease affects the valves with the following predilection:
mitral valve > aortic valve > tricuspid valve > pulmonary valve.
Grossly, vegetations form along lines of valve closure and are generally symmetric with a smooth or verrucoid (warty) texture. Histologically, lesions are composed of fibrin (eosinophilic) and platelets but, unlike bacterial etiologies, contain little evidence of PMNs, microorganisms or inflammation.
Due to the non-invasive nature of NBTE, clinical examination may or may not reveal a new murmur.
It is imperative to take the blood pressure in both arms.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]