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Health Dictionary

Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Marfan's syndrome future or investigational therapies

Introduction

Editors-In-Chief: William James Gibson, C. Michael Gibson, M.S., M.D.

Overview

Overview

Future Therapies and Investigations

Future Therapies and Investigations

  • Research in laboratory mice has suggested that the angiotensin II receptor antagonist losartan, which appears to block TGF-beta activity, can slow or halt the formation of aortic aneurysms in Marfan syndrome.[1] A large clinical trial sponsored by the National Institutes of Health comparing the effects of losartan and atenolol on the aortas of Marfan patients is scheduled to begin in early 2007, coordinated by Johns Hopkins.[2]
  • There is no cure for Marfan syndrome, but life expectancy has increased significantly over the last few decades, and clinical trials are underway for a promising new treatment. The syndrome is treated by addressing each issue as it arises, and, in particular, considering prophylactic medication, even for young children, to slow progression of aortic dilation.
References

References

  1. ↑ Habashi, Jennifer P. (April 7, 2006). “Losartan, an AT1 Antagonist, Prevents Aortic Aneurysm in a Mouse Model of Marfan Syndrome”. 312 (5770): 117–121. doi:10.1126/science.1124287. Unknown parameter |news= ignored (|newspaper= suggested) (help); Unknown parameter |abstract= ignored (help); Unknown parameter |coauthors= ignored (help)
  2. ↑ “Atenolol vs. Losartan in Individuals with Marfan Syndrome Clinial Trial”. National Marfan Foundation.

Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [1] ; Cassandra Abueg, M.P.H. [2]