Physical examination for mast cell tumor include inspection for a large assortment of types of skin lesions, testing for dermatographism (Darier’s sign), and palpating for hepatosplenomegaly and lymphadenopathy.

• Hypotension
• Tachycardia

• Urticaria pigmentosa:^[1]

• Fixed, reddish brown lesions appears as maculo-papules, plaques, nodules, or blisters.^[2]
• Urticaria Pigmentosa (UP) lesions tend to be larger, better delineated, and more hyperpigmented in children, as compared to adults, who tend to have numerous small lesions that coalesce to form mottled areas.
• The trunk and thigh are more commonly involved with sparing of face, palms and soles.

• Darier’s sign:^[3]

• Lesions urticate in response to physical irritation.
• Localized erythema and urticaria erupts within short period of time (minutes) in response to physical irritation.

• Diffuse Cutaneous Mastocytosis

• Diffuse infiltrative yellow-orange xanthogranuloma-like subcutaneous nodules, or as a widespread urticarial eruption with bullae and redness.^[2]

• Telangiectasia macularis eruptiva perstans^[4]
  • It is a rare form of mastocytosis, and presents as brownish macules and telangiectasia.
  • Not associated with pruritus and blistering.

• Hepatomegaly
• Splenomegaly

• 
  Mastocytoma.
  Adapted from Atlas<ref name=”www.atlasdermatologico.com.br”>“Dermatology Atlas”.
• 
  Mastocytoma.
  Adapted from Atlas<ref name=”www.atlasdermatologico.com.br”>“Dermatology Atlas”.
• 
  Mastocytoma.
  Adapted from Atlas<ref name=”www.atlasdermatologico.com.br”>“Dermatology Atlas”.
• 
  Mastocytoma.
  Adapted from Atlas<ref name=”www.atlasdermatologico.com.br”>“Dermatology Atlas”.