Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Medullary thyroid cancer causes
Introduction
Causes
Causes
- Development of sporadic medullary thyroid cancer is the result of somatic mutation of RET proto-oncogene.[1][2][3]
- Hereditary form of medullary thyroid cancer is the result of germline mutation of RET proto-oncogene that are associated with MEN 2 syndromes.
Reference
Reference
- ↑ Thyroid Cancer Cancer.gov (2015). http://www.cancer.gov/types/thyroid/hp/thyroid-treatment-pdq#link/stoc_h2_2- Accessed on October, 29 2015
- ↑ Raue F (October 1998). “German medullary thyroid carcinoma/multiple endocrine neoplasia registry. German MTC/MEN Study Group. Medullary Thyroid Carcinoma/Multiple Endocrine Neoplasia Type 2”. Langenbecks Arch Surg. 383 (5): 334–6. PMID 9860226.
- ↑ Marsh DJ, Andrew SD, Eng C, Learoyd DL, Capes AG, Pojer R, Richardson AL, Houghton C, Mulligan LM, Ponder BA, Robinson BG (March 1996). “Germline and somatic mutations in an oncogene: RET mutations in inherited medullary thyroid carcinoma”. Cancer Res. 56 (6): 1241–3. PMID 8640806.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]