Medulloblastoma epidemiology and demographics

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2] Syed Musadiq Ali M.B.B.S.[3]

Overview

Medulloblastoma is the second most common brain tumor among the pediatric population.^[1] The overall age adjusted incidence rate of medulloblastoma is approximately 0.71 per 100,000 individuals in the United States.^[2] The incidence of medulloblastoma decreases with age; the median age at diagnosis is between 5 to 7 years.^[3] Males are more commonly affected with medulloblastoma than females. The male to female ratio is approximately 1.44 to 1.^[2]

Epidemiology and Demographics

Prevalence

Medulloblastoma is the second most common brain tumor among the pediatric population.^[1]
Medulloblastoma is considered a rare tumor among adults, as it comprises fewer than 2% of all brain tumors among that age group.

Incidence

The overall age adjusted incidence rate of medulloblastoma is approximately 0.71 per 100,000 individuals in the United States.^[2]

Age

The incidence of medulloblastoma decreases with age; the median age at diagnosis is between 5 to 7 years.^[3]
The molecular subgroup of medulloblastoma has an influence on the age of presentation such as:^[4]

WNT medulloblastoma subgroup presents among older children
SHH medulloblastoma subgroup presents among infants and adults
Group 3 medulloblastoma presents among younger children
Group 4 medulloblastoma presents among younger children

Gender

The overall age adjusted incidence rate of medulloblastoma among males is approximately 0.84 per 100,000 individuals in the United States.^[2]
The overall age adjusted incidence rate of medulloblastoma among females is approximately 0.58 per 100,000 individuals in the United States.
Males are more commonly affected with medulloblastoma than females. The male to female ratio is approximately 1.44 to 1.

Race

There is no racial predilection to medulloblastoma.^[5]

References

↑ ^1.0 ^1.1 Medulloblastoma. Wikipedia(2015) https://en.wikipedia.org/wiki/Medulloblastoma Accessed on September, 28th 2015
↑ ^2.0 ^2.1 ^2.2 ^2.3 McKean-Cowdin R, Razavi P, Barrington-Trimis J, Baldwin RT, Asgharzadeh S, Cockburn M; et al. (2013). “Trends in childhood brain tumor incidence, 1973-2009”. J Neurooncol. 115 (2): 153–60. doi:10.1007/s11060-013-1212-5. PMC 4056769. PMID 23925828.
↑ ^3.0 ^3.1 Bartlett F, Kortmann R, Saran F (2013). “Medulloblastoma”. Clin Oncol (R Coll Radiol). 25 (1): 36–45. doi:10.1016/j.clon.2012.09.008. PMID 23245832.
↑ Leary SE, Olson JM (2012) The molecular classification of medulloblastoma: driving the next generation clinical trials. Curr Opin Pediatr 24 (1):33-9. DOI:10.1097/MOP.0b013e32834ec106 PMID: 22189395
↑ Roberts RO, Lynch CF, Jones MP, Hart MN (1991). “Medulloblastoma: a population-based study of 532 cases”. J Neuropathol Exp Neurol. 50 (2): 134–44. PMID 2010773.

Template:WikiDoc Sources

[wiki-1] 1.0 ^1.1 Medulloblastoma. Wikipedia(2015) https://en.wikipedia.org/wiki/Medulloblastoma Accessed on September, 28th 2015

[pmid23925828-2] 2.0 ^2.1 ^2.2 ^2.3 McKean-Cowdin R, Razavi P, Barrington-Trimis J, Baldwin RT, Asgharzadeh S, Cockburn M; et al. (2013). “Trends in childhood brain tumor incidence, 1973-2009”. J Neurooncol. 115 (2): 153–60. doi:10.1007/s11060-013-1212-5. PMC 4056769. PMID 23925828.

[pmid23245832-3] 3.0 ^3.1 Bartlett F, Kortmann R, Saran F (2013). “Medulloblastoma”. Clin Oncol (R Coll Radiol). 25 (1): 36–45. doi:10.1016/j.clon.2012.09.008. PMID 23245832.

[pmid22189395-4] Leary SE, Olson JM (2012) The molecular classification of medulloblastoma: driving the next generation clinical trials. Curr Opin Pediatr 24 (1):33-9. DOI:10.1097/MOP.0b013e32834ec106 PMID: 22189395

[pmid2010773-5] Roberts RO, Lynch CF, Jones MP, Hart MN (1991). “Medulloblastoma: a population-based study of 532 cases”. J Neuropathol Exp Neurol. 50 (2): 134–44. PMID 2010773.

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