Megaloblastic anemia (patient information)

Megaloblastic anemia is a blood disorder in which there is anemia with larger-than-normal red blood cells.

Anemia is a condition in which the body does not have enough healthy red blood cells. Red blood cells provide oxygen to body tissues.

• People with mild anemia may have no symptoms, or symptoms may be very mild.

• More typical symptoms of vitamin B12 deficiency anemia include:

• Diarrhea or constipation
• Fatigue, lack of energy, or light-headedness when standing up or with exertion
• Loss of appetite
• Pale skin
• Problems concentrating
• Shortness of breath, mostly during exercise
• Swollen, red tongue or bleeding gums

• Megaloblastic anemia is usually caused by a deficiency of folic acid or vitamin B12.

• Other less common causes are:

• Alcohol abuse
• Certain inherited disorders
• Drugs that affect DNA, such as chemotherapy drugs
• Leukemia
• Myelodysplastic syndrome
• Myelofibrosis
• The anticonvulsant drug dilantin

Risk factors relate to the causes.

Call your health care provider if you have any of the symptoms of anemia.

• A physical exam may show problems with reflexes or a positive Babinski reflex.

• The following tests may be done:

• Complete blood count
• Reticulocyte count
• Schilling test (if pernicious anemia is suspected)
• Serum LDH
• Serum vitamin B12 level and serum folate levels

• Esophagogastroduodenoscopy (EGD) to examine the stomach, or enteroscopy to examine the small intestine may be done.

• Bone marrow biopsy is done only when the diagnosis is not clear.

Treatment depends on the cause of B12 and folate deficiencies.

Directions to Hospitals Treating Megaloblastic anemia

Anemia usually responds well to treatment within 2 months.

http://www.nlm.nih.gov/medlineplus/ency/article/000567.htm

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