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Melanin-concentrating hormone receptor
Introduction
Two Melanin-concentrating hormone receptors (MCHR) have recently been characterized: MCH-R1 and MCH-R2. These two receptors share approximately 38% homology.
- MCH-R1 is expressed in all mammals.
- MCH-R2 is only found in some primates and carnivores including dogs, ferrets and humans.
Clinical significance
Clinical significance
Antagonists might be useful in the treatment of obesity[1][2] and anxiety and depression.[3] An agonist might have possible utility as a treatment for osteoporosis[4] and insomnia[5]
Research is ongoing for antagonists affecting MCH receptors R1 and R2.[6][7]
References
References
- ↑ Handlon AL, Zhou H (2006). “Melanin-concentrating hormone-1 receptor antagonists for the treatment of obesity”. J. Med. Chem. 49 (14): 4017–22. doi:10.1021/jm058239j. PMID 16821761.
- ↑ Luthin DR (2007). “Anti-obesity effects of small molecule melanin-concentrating hormone receptor 1 (MCHR1) antagonists”. Life Sci. 81 (6): 423–40. doi:10.1016/j.lfs.2007.05.029. PMID 17655875.
- ↑ Shimazaki T, Yoshimizu T, Chaki S (2006). “Melanin-concentrating hormone MCH1 receptor antagonists: a potential new approach to the treatment of depression and anxiety disorders”. CNS Drugs. 20 (10): 801–11. doi:10.2165/00023210-200620100-00002. PMID 16999451.
- ↑ Bohlooly-Y M, Mahlapuu M, Andersén H, Astrand A, Hjorth S, Svensson L, Törnell J, Snaith MR, Morgan DG, Ohlsson C (2004). “Osteoporosis in MCHR1-deficient mice”. Biochem. Biophys. Res. Commun. 318 (4): 964–9. doi:10.1016/j.bbrc.2004.04.122. PMID 15147966.
- ↑ Monti JM, Torterolo P, Lagos P (August 2013). “Melanin-concentrating hormone control of sleep-wake behavior”. Sleep Med Rev. 17 (4): 293–8. doi:10.1016/j.smrv.2012.10.002. PMID 23477948.
- ↑ Saito Y, Maruyama K (2006). “Identification of melanin-concentrating hormone receptor and its impact on drug discovery”. J. Exp. Zoolog. Part a Comp. Exp. Biol. 305 (9): 761–8. doi:10.1002/jez.a.311. PMID 16902961.
- ↑ McBriar MD (2006). “Recent advances in the discovery of melanin-concentrating hormone receptor antagonists”. Current Opinion in Drug Discovery & Development. 9 (4): 496–508. PMID 16889232.
External links
External links
- “Melanin-Concentrating Hormone Receptors”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
- melanin-concentrating+hormone+receptor at the US National Library of Medicine Medical Subject Headings (MeSH)
- MCHR1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- MCHR2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)