Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Membranous glomerulonephritis laboratory findings
Introduction
Overview
Overview
The major laboratory workup includes blood workup like complete blood count, auto-immune workup ANA, antidsDNA, anti-Sm, anti-Ro/SSA, and anti-La/SSBand, Anti–PLA2R antibody, urine workup like 24 hours urine collection for protein quantification.
Laboratory Findings
Laboratory Findings
- The laboratory workup of membranous glomerulonephritis includes blood, urine and anti-bodies workup:[1][2]
- Comprehensive chemistry panel including serum albumin
- Complete blood count
- Urinalysis with examination of the sediment
- 24-hour urine collection for protein quantification and creatinine clearance
- ANA and, if positive, anti-double-stranded DNA (antidsDNA), anti-Sm, anti-Ro/SSA, and anti-La/SSB antibodies to rule out autoimmune disease (SLE)
- Tests for hepatitis B and C viruses and the human immunodeficiency virus (HIV)
- Serum C3 and C4 complement levels
- Serum free light chains (SFLCs) and serum protein electrophoresis (SPEP) with immunofixation
- Phospholipase-A2-receptor antibody (Anti–PLA2R antibody) by enzyme-linked immunosorbent assay (ELISA)
References
References
- ↑ Qin W, Beck LH, Zeng C, Chen Z, Li S, Zuo K, Salant DJ, Liu Z (June 2011). “Anti-phospholipase A2 receptor antibody in membranous nephropathy”. J. Am. Soc. Nephrol. 22 (6): 1137–43. doi:10.1681/ASN.2010090967. PMC 3103733. PMID 21566055.
- ↑ Hofstra JM, Debiec H, Short CD, Pellé T, Kleta R, Mathieson PW, Ronco P, Brenchley PE, Wetzels JF (October 2012). “Antiphospholipase A2 receptor antibody titer and subclass in idiopathic membranous nephropathy”. J. Am. Soc. Nephrol. 23 (10): 1735–43. doi:10.1681/ASN.2012030242. PMC 3458465. PMID 22956816.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Syed Ahsan Hussain, M.D.[2]