Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Mesangial proliferative glomerulonephritis
Introduction
Overview
Overview
Mesangial proliferative glomerulonephritis is a form of glomerulonephritis associated primarily with the mesangium.[1]
There is some evidence that interleukin-10 may inhibit it in an animal model.[2]
It is classified as type II lupus nephritis by the WHO.
References
- ↑ “Definition: mesangial proliferative glomerulonephritis from Online Medical Dictionary”.
- ↑ Kitching AR, Katerelos M, Mudge SJ, Tipping PG, Power DA, Holdsworth SR (2002). “Interleukin-10 inhibits experimental mesangial proliferative glomerulonephritis”. Clin. Exp. Immunol. 128 (1): 36–43. PMC 1906377. PMID 11982588. Unknown parameter
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Historical Perspective
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References
Classification
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References
Pathophysiology
Overveiw
Pathophysiology
Mesangial cells in the renal glomerulus use endocytosis to take up and degrade circulating immunoglobulin. This normal process stimulates mesangial cell proliferation and matrix deposition. Therefore, during times of elevated circulating immunoglobulin (i.e. lupus and IgA nephropathy) one would expect to see an increased number of mesangial cells and matrix in the glomerulus. This is characteristic of nephritic syndromes.
References
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Differentiating Mesangial proliferative glomerulonephritis from other Diseases
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References
Epidemiology and Demographics
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Risk Factors
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Screening
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Natural History, Complications and Prognosis
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Diagnosis
Diagnosis
History and Symptoms | Physical Examination | Laboratory Findings | CT | MRI | Ultrasound | Other Imaging Findings | Other Diagnostic Studies
Treatment
Treatment
Medical Therapy | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]