Mesoblastic nephroma pathophysiology

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2]

Overview

On gross pathology, a solid nonencapsulated mass that often occurs near the renal hilum is the characteristic finding of mesoblastic nephroma. On microscopic histopathological analysis, spindle cell is the characteristic finding of classic mesoblastic nephroma; whereas, plump cells with vesicular nuclei is the characteristic finding of cellular mesoblastic nephroma.^[1]

Genetics

Translocation t(12:15)(p13;q25) that generates the fusion of ETV6/NTRK3 gene is involved in the pathogenesis of mesoblastic nephroma.^[2]

Gross Pathology

Characteristic findings of mesoblastic nephroma include:^[3]

Solid nonencapsulated mass
Often occurs near the renal hilum
Tends to invade the surrounding structures and renal parenchyma
Hemorrhage and necrosis are infrequent

Microscopic Pathology

Classic mesoblastic nephroma^[4]

Spindle cells in fascicles
Infiltrative border

Cellular mesoblastic nephroma

Plump cells with vesicular nuclei
Well-defined border
Mitotically active

Mixed mesoblastic nephroma

Both classic pattern and cellular pattern areas are present

References

↑ Humphrey, Peter (2008). The Washington manual of surgical pathology. Philadelphia: Lippincott Williams & Wilkins. ISBN 978-0781765275.
↑ Knezevich SR, McFadden DE, Tao W, Lim JF, Sorensen PH (1998). “A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma”. Nature Genetics. 18 (2): 184–7. doi:10.1038/ng0298-184. PMID 9462753.
↑ Mesoblastic nephroma.Dr Ayush Goel and Dr Yuranga Weerakkody et al. Radiopaedia.org 2015. http://radiopaedia.org/articles/mesoblastic-nephroma
↑ Humphrey, Peter (2008). The Washington manual of surgical pathology. Philadelphia: Lippincott Williams & Wilkins. ISBN 978-0781765275.

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[1] Humphrey, Peter (2008). The Washington manual of surgical pathology. Philadelphia: Lippincott Williams & Wilkins. ISBN 978-0781765275.

[pmid9462753-2] Knezevich SR, McFadden DE, Tao W, Lim JF, Sorensen PH (1998). “A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma”. Nature Genetics. 18 (2): 184–7. doi:10.1038/ng0298-184. PMID 9462753.

[radio-3] Mesoblastic nephroma.Dr Ayush Goel and Dr Yuranga Weerakkody et al. Radiopaedia.org 2015. http://radiopaedia.org/articles/mesoblastic-nephroma

[4] Humphrey, Peter (2008). The Washington manual of surgical pathology. Philadelphia: Lippincott Williams & Wilkins. ISBN 978-0781765275.

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