Metabolic acidosis future or investigational therapies

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Small animal studies of various models of shock and lactic acidosis demonstrated improved cardiac function, reduced mortality, and decreased generation of pro-inflammatory cytokines; human studies yet to be performed, so options include as follows:

1. Dichloroacetate
2. Administration of selective inhibitors Na+-H+ Exchanger 1 or amiloride analogues
3. Administration of inhibitors of transient receptor potential vanilloid 1
4. Administration of selective inhibitors acid sensing Ion channel la
5. Administration of inhibitors of mitogen activated protein kinase

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