Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Metabolic acidosis future or investigational therapies
Introduction
Experimental Treatment:
Small animal studies of various models of shock and lactic acidosis demonstrated improved cardiac function, reduced mortality, and decreased generation of pro-inflammatory cytokines; human studies yet to be performed, so options include as follows:
- Dichloroacetate
- Administration of selective inhibitors Na+-H+ Exchanger 1 or amiloride analogues
- Administration of inhibitors of transient receptor potential vanilloid 1
- Administration of selective inhibitors acid sensing Ion channel la
- Administration of inhibitors of mitogen activated protein kinase
References
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]