Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Methdilazine
Introduction
Overview
Overview
Methdilazine (Dilosyn, Tacaryl) is a first-generation antihistamine with anticholinergic properties of the phenothiazine class.
References
References
- Rani Basu L, Mazumdar K, Dutta N, Karak P, Dastidar S (2005). “Antibacterial property of the antipsychotic agent prochlorperazine, and its synergism with methdilazine”. Microbiol Res. 160 (1): 95–100. doi:10.1016/j.micres.2004.10.002. PMID 15782943.
- Chattopadhyay D, Mukherjee T, Pal P, Saha B, Bhadra R (1998). “Altered membrane permeability as the basis of bactericidal action of methdilazine”. J Antimicrob Chemother. 42 (1): 83–6. doi:10.1093/jac/42.1.83. PMID 9700532.
- Chattopadhyay D, Dastidar S, Chakrabarty A (1988). “Antimicrobial properties of methdilazine and its synergism with antibiotics and some chemotherapeutic agents”. Arzneimittelforschung. 38 (7): 869–72. PMID 2905130.
The ring-contracted analog, methdilazine, interestingly enough shows only very weak activity as a tranquilizer; instead, that agent constitutes an important antihistamine.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]