Health Dictionary
Reliable, easy-to-read patient information on common medical conditions â written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Methyprylon
Introduction
Methyprylon (Noludar) is a sedative of the piperidinedione derivative family developed by Hoffmann-La Roche.[1] This medicine was used for treating insomnia, but is now rarely used as it has been replaced by newer drugs with fewer side effects, such as benzodiazepines.[2] Methyprylon was withdrawn from the US market in June 1989 and the Canadian market in September 1990. Some other trade names are Noctan and Dimerin.
Adverse effects
Adverse effects
Side effects can include skin rash, fever, depression, ulcers or sores in mouth or throat, unusual bleeding or bruising, confusion, fast heartbeat, respiratory depression, swelling of feet or lower legs, dizziness, drowsiness, headache, double vision, clumsiness, constipation, diarrhea, nausea, vomiting, unusual weakness.
Pharmacokinetics
Pharmacokinetics
A study of single oral doses of 300Â mg in healthy volunteers found that the zero-order absorption model fit the data best. Mean (+/- SD) values for the half-life (9.2 +/- 2.2 h), apparent clearance, (11.91 +/- 4.42 mL/h/kg) and apparent steady-state volume of distribution, (0.97 +/- 0.33 L/kg) were found.[3]
A case report found that the pharmacokinetics of methyprylon were not concentration dependent in an overdose case; explanations included saturation or inhibition of metabolic pathways. The generally accepted half-life for a therapeutic dose was not found appropriate in intoxicated patients and would underestimate the time required to reach a safe concentration of the drug.[4]
References
References
- â US patent 2680116, Frick, H. & Lutz, A. H., “Piperidiones and Process for the Manufacture thereof”, issued 1954-06-01, assigned to Hoffmann-La Roche
- â PMID 16792 (PMIDÂ 16792)
Citation will be completed automatically in a few minutes. Jump the queue or expand by hand - â PMID 2866242 (PMIDÂ 2866242)
Citation will be completed automatically in a few minutes. Jump the queue or expand by hand - â PMID 1686463 (PMIDÂ 1686463)
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] == Overview ==