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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Microangiopathic hemolytic anemia classification

Introduction

Mydah Sajid, MD [1]

Classification

Classification

Microangiopathic hemolytic anemia may be classified into primary subtype based on the genetic mutations and no known underlying disease and secondary subtype due to known underlying cause^[1].

Primary:
- Thrombotic thrombocytopenic purpura
  - Congenital
  - Acquired
- Hemolytic Uremic Syndrome
  - Shiga toxin E-coli
  - Atypical

Secondary:
- Malignant hypertension
- Pregnancy
  - Pre-eclampsia, Eclampsia
  - Thrombotic microangiopathy
  - Hemolysis, elevated liver enzymes, low platelet count (HELLP syndrome)
- Drug or toxin mediated:
  - calcineurin inhibitors, quinine
- Viral infections:
- Cancer
- Disseminated intravascular coagulation
- Solid organ or bone marrow transplantation
- Nutritional deficiency: Vitamin B12 or vitamin C deficiency

References

References

↑ Arnold DM, Patriquin CJ, Nazy I (2017). “Thrombotic microangiopathies: a general approach to diagnosis and management”. CMAJ. 189 (4): E153–E159. doi:10.1503/cmaj.160142. PMC 5266569. PMID 27754896.