Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Microscopic polyangiitis causes
Introduction
Overview
Overview
There are no known direct causes for Microscopic polyangiitis. Microscopic polyangiitis can affect individuals from all ethnicities and of any age group.Vasculitis is a common term that refers to inflammation of the blood vessels in the body. When the inflammation progress it lead to weakening and stretch of the blood vessels and forms a an aneurysm.
Causes
Causes
Common Causes
There are no known direct common causes for Microscopic polyangiitis. However microscopic polyangiitis may be caused by:[1][2][3]
- Autoimmune mechanism
- Infections
- Drugs
Less Common Causes
- Silica exposure
- Malignancy
Genetic Causes
- HLA-DRB1*09:01-DQB1*03:03 haplotype genes shows a significant increase in the association with Microscopic polyangiitis.[4]
- These haplotypes are mostly found in Japanese population.[5]
- Activation of NK/ T cells may also lead to predisposition to Microscopic polyangiitis.[6][7]
References
References
- ↑ Kallenberg CG, Rarok A, Stegeman CA, Limburg PC (February 2002). “New insights into the pathogenesis of antineutrophil cytoplasmic autoantibody-associated vasculitis”. Autoimmun Rev. 1 (1–2): 61–6. PMID 12849060.
- ↑ Hogan SL, Cooper GS, Savitz DA, Nylander-French LA, Parks CG, Chin H, Jennette CE, Lionaki S, Jennette JC, Falk RJ (March 2007). “Association of silica exposure with anti-neutrophil cytoplasmic autoantibody small-vessel vasculitis: a population-based, case-control study”. Clin J Am Soc Nephrol. 2 (2): 290–9. doi:10.2215/CJN.03501006. PMC 4049534. PMID 17699427.
- ↑ Tsuchiya N (2012). “Genetics of microscopic polyangiitis in the Japanese population”. Ann Vasc Dis. 5 (3): 289–95. doi:10.3400/avd.ra.12.00062. PMC 3595849. PMID 23555527.
- ↑ Tsuchiya N (2012). “Genetics of microscopic polyangiitis in the Japanese population”. Ann Vasc Dis. 5 (3): 289–95. doi:10.3400/avd.ra.12.00062. PMC 3595849. PMID 23555527.
- ↑ Tsuchiya N, Kobayashi S, Hashimoto H, Ozaki S, Tokunaga K (January 2006). “Association of HLA-DRB1*0901-DQB1*0303 haplotype with microscopic polyangiitis in Japanese”. Genes Immun. 7 (1): 81–4. doi:10.1038/sj.gene.6364262. PMID 16208405.
- ↑ Naumova E, Mihaylova A, Stoitchkov K, Ivanova M, Quin L, Toneva M (February 2005). “Genetic polymorphism of NK receptors and their ligands in melanoma patients: prevalence of inhibitory over activating signals”. Cancer Immunol. Immunother. 54 (2): 172–8. doi:10.1007/s00262-004-0575-z. PMID 15248031.
- ↑ Miyashita R, Tsuchiya N, Yabe T, Kobayashi S, Hashimoto H, Ozaki S, Tokunaga K (March 2006). “Association of killer cell immunoglobulin-like receptor genotypes with microscopic polyangiitis”. Arthritis Rheum. 54 (3): 992–7. doi:10.1002/art.21653. PMID 16508981.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2]