Minimal change disease (MCD) is considered a disease of childhood. It is responsible for up to 70-90% of nephrotic syndrome in patients less than 10 years of age, and up to 50% of older children. Among children, several studies have shown a male predominance with approximately 2:1 male to female ratio.

• The incidence of Minimal change disease (MCD) is approximately 2-7 per 100,000 individuals worldwide.^[1][2]

• The prevalence of Minimal change disease (MCD) is not known.^[3]
• The prevalence of Minimal change disease (MCD) is approximately 10–50 cases per 100,000 individuals worldwide.^[4]

• Minimal change disease (MCD) is considered a disease of childhood.
• It is responsible for up to 70-90% of nephrotic syndrome in patients less than 10 years of age, and up to 50% of older children.^[5][6][7]

• MCD is much less common in the adult population. Nonetheless, it still accounts for 10-15% of nephrotic syndromes in adults.^[8][7]

• Among children, several studies have shown a male predominance with approximately 2:1 male to female ratio.^{[9] [10]}
• However, gender differences in pediatric and adult MCD have not been consistent throughout the literature.
• In one study that recruited 95 adult patients with MCD over a 15-year period, results showed that 80% of subjects are white with a slight female predominance (60%).^[9]
• Among adults, the median age for presentation is approximately 30-40 years.^[11]

• MCD is more common in Asia (approximately 2:1) than it is in North America or Europe.^{[12] [13]}
• It has been reported to be as rare as 1 case per million in USA.^[14][15]
• The reason behind such discrepancy is unknown; but it is believed to be due to variations in routine work-up procedures and diagnostic clinical practices.