Minimal change disease historical perspective

Minimal change disease was first described by F. Munk in 1913, when he coined the term “lipoid nephrosis” following the observation of lipid-laden macrophages in the proximal tubular epithelial cells and oval fat bodies in urine. In 1925, Fahr and colleagues noted the resemblance of minimal change disease to focal segmental glomerulosclerosis (FSGS). Ever since its early description, the term “lipoid nephrosis” has been criticized due to the clinical irrelevance of the lipid-laden cells seen on microscopy.

• The term “lipoid nephrosis,” introduced in the early 1900s in which microscopic lipid droplets in urine and tubular cells were noticed in minimal change disease.^[1][2]

• Minimal change disease was discovered, in 1950s during ultra-structural analyses and extensive fusion of podocyte foot processes was observed.^[3][4]

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