Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Mixed connective tissue disease historical perspective
Introduction
Overview
Overview
In 1972, Gordon C.Sharp was the first physician who defined MCTD. It has been the first rheumatic disease syndrome that has represented by a serologic test. In 1976, Alarcon-Segovia proposed criteria for MCTD classifying between all types of connective tissue diseases. It represents the close association between MCTD and Sjogren’s syndrome.
Historical Perspective
Historical Perspective
- In 1972, Gordon C.Sharp was the first physician who defined MCTD.
- MCTD has been the first rheumatic disease syndrome that has represented by a serologic test (positive U1RNP).[1][2]
- In 1976, Alarcon-Segovia proposed criteria for MCTD classifying between all types of connective tissue diseases. It represents the close association between MCTD and Sjogren’s syndrome.
- In 1987, Sharp, Alarcon-Segovia and The Research Committee of Japanese Ministry of Health and Welfare for MCTD (JMHW) suggested three groups of criteria for diagnosing MCTD.[3]
References
References
- ↑ Vij M, Agrawal V, Jain M (July 2014). “Scleroderma renal crisis in a case of mixed connective tissue disease”. Saudi J Kidney Dis Transpl. 25 (4): 844–8. PMID 24969199.
- ↑ Hoffman RW, Maldonado ME (July 2008). “Immune pathogenesis of Mixed Connective Tissue Disease: a short analytical review”. Clin. Immunol. 128 (1): 8–17. doi:10.1016/j.clim.2008.03.461. PMID 18439877.
- ↑ Alarcón-Segovia D (October 1984). “Symptomatic Sjögren’s syndrome in mixed connective tissue disease”. J. Rheumatol. 11 (5): 582–3. PMID 6512789.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shaghayegh Habibi, M.D.[2]