Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Mixed connective tissue disease laboratory tests
Introduction
Overview
Overview
Laboratory findings consistent with the diagnosis of MCTD include antibodies against the U1RNP, positive rheumatoid factor (RF), elevated CRP levels, hypergammaglobulinemia, anemia, leucopenia, circulating immune complexes, and hypocomplementemia.
Laboratory Findings
Laboratory Findings
- Laboratory findings consistent with the diagnosis of MCTD include:[1][2][3]
- Antibodies against the U1-ribonucleoprotein complex (anti U1RNP)
- Rheumatoid factor (RF) positive
- Complete blood count may shows:
- Circulating immune complexes
- Hypocomplementemia
- Elevated CRP levels[4]
- Hypergammaglobulinemia[5]
References
References
- ↑ Mimura Y, Ihn H, Jinnin M, Asano Y, Yamane K, Tamaki K (July 2006). “Rheumatoid factor isotypes in mixed connective tissue disease”. Clin. Rheumatol. 25 (4): 572–4. doi:10.1007/s10067-005-0185-y. PMID 16391886.
- ↑ Ruiz Pombo M, Labrador Horrillo M, Selva O’Callaghan A (November 2004). “[Undifferentiated, overlapping and mixed connective tissue diseases]”. Med Clin (Barc) (in Spanish; Castilian). 123 (18): 712–7. PMID 15563821.
- ↑ LatuÅ›kiewicz-Potemska J, Zygmunt A, Biernacka-ZieliÅ„ska M, StaÅ„czyk J, Smolewska E (October 2013). “Mixed connective tissue disease presenting with progressive scleroderma symptoms in a 10-year-old girl”. Postepy Dermatol Alergol. 30 (5): 329–36. doi:10.5114/pdia.2013.38365. PMC 3858664. PMID 24353496.
- ↑ Bakri Hassan A, Rönnelid J, Gunnarsson I, Karlsson G, Berg L, Lundberg I (October 1998). “Increased serum levels of immunoglobulins, C-reactive protein, type 1 and type 2 cytokines in patients with mixed connective tissue disease”. J. Autoimmun. 11 (5): 503–8. doi:10.1006/jaut.1998.0236. PMID 9802936.
- ↑ Hämeenkorpi R, Ruuska P, Forsberg S, Tiilikainen R, Mäkitalo R, Hakala M (1993). “More evidence of distinctive features of mixed connective tissue disease”. Scand. J. Rheumatol. 22 (2): 63–8. PMID 8480140.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shaghayegh Habibi, M.D.[2]