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Health Dictionary

Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Monoclonal gammopathy of undetermined significance historical perspective

Introduction

Overview

Overview

Monoclonal gammopathy of undetermined significance was first discivered by Jan G. Waldenstrom in 1960 “essential hyperglobulinemia” or “benign monoclonal gammopathy” and then as monoclonal gammopathy of undetermined significance by Robert A. Kyle in 1978. Introduced more than 35 years ago, the term monoclonal gammopathy of undetermined signficance was used because of the increased risk of patients for the development of symptomatic MM, WM, Light-chain (AL) amyloidosis, or a related disorder during long-term follow-up.

Historical Perspective

Historical Perspective

Discovery

Monoclonal gammopathy of undetermined significance was first discivered by Jan G. Waldenstrom in 1960 “essential hyperglobulinemia” or “benign monoclonal gammopathy” and then as monoclonal gammopathy of undetermined significance by Robert A. Kyle in 1978. [1] Introduced more than 35 years ago, the term monoclonal gammopathy of undetermined signficance was used because of the increased risk of patients for the development of symptomatic MM, WM, light-chain (AL) amyloidosis, or a related disorder during long-term follow-up.[2][3]

References

References

  1. ↑ WALDENSTROM J (1960). “Studies on conditions associated with disturbed gamma globulin formation (gammopathies)”. Harvey Lect. 56: 211–31. PMID 14004528.
  2. ↑ Kyle RA, Therneau TM, Rajkumar SV, Larson DR, Plevak MF, Melton LJ (July 2004). “Long-term follow-up of 241 patients with monoclonal gammopathy of undetermined significance: the original Mayo Clinic series 25 years later”. Mayo Clin. Proc. 79 (7): 859–66. doi:10.1016/S0025-6196(11)62151-4. PMID 15244381.
  3. ↑ Kyle RA (May 1978). “Monoclonal gammopathy of undetermined significance. Natural history in 241 cases”. Am. J. Med. 64 (5): 814–26. PMID 645746.

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Omer Kamal, M.D.[2]