Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Monoclonal gammopathy of undetermined significance laboratory findings
Introduction
Overview
Overview
Patients may be diagnosed with MGUS if they fulfill the three component criteria which includes a monoclonal paraprotein band less than 3 g/dl, plasma cells less than 10% on bone marrow examination, and no evidence of bone lesions, anemia, hypercalcemia, or renal insufficiency related to the paraprotein. Peripheral blood should be assessed for hypercalcemia and deterioration in renal function, and urine should be assessed for Bence-Jones protein.
Laboratory Findings
Laboratory Findings
- Patients may be diagnosed with MGUS if they fulfill the following three criteria:[1]
- A monoclonal paraprotein band less than 3 g/dl
- Plasma cells less than 10% on bone marrow examination
- No evidence of bone lesions, anemia, hypercalcemia, or renal insufficiency related to the paraprotein
- Urine should not show Bence-Jones protein
- Serum free light chain (FLC) assay should be assessed in urine and blood
- Immunoglobulins quantitation can be done but is not necessary
References
References
- ↑ International Myeloma Working Group (2003). “Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group”. Br J Haematol. 121 (5): 749–57. PMID 12780789.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2] Associate Editor(s)-in-Chief: Omer Kamal, M.D.[3]