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Monoclonal gammopathy of undetermined significance other diagnostic studies

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Omer Kamal, M.D.[2]

Overview

Overview

The protein electrophoresis test should be repeated annually, and if there is any concern for a rise in the level of monoclonal protein, then prompt referral to a haematologist is required. A bone marrow biopsy should be performed.

Other Diagnostic Studies

Other Diagnostic Studies

Protein Electrophoresis

The protein electrophoresis test should be repeated annually, and if there is any concern for a rise in the level of monoclonal protein, then prompt referral to a haematologist is required.[1][2]

Bone Marrow Biopsy

A bone marrow biopsy should be performed because a diagnosis of MGUS requires the presence of less than 10% clonal plasma cells.[1][2]

References

References

  1. 1.0 1.1 Jang ST, Sohn IS, Jin ES, Cho JM, Kim CJ, Lim SJ (April 2009). “A case of cardiac dysfunction associated with monoclonal gammopathy of undetermined significance”. J. Korean Med. Sci. 24 (2): 354–6. doi:10.3346/jkms.2009.24.2.354. PMC 2672144. PMID 19399286.
  2. 2.0 2.1 Mangiacavalli S, Cocito F, Pochintesta L, Pascutto C, Ferretti V, Varettoni M, Zappasodi P, Pompa A, Landini B, Cazzola M, Corso A (October 2013). “Monoclonal gammopathy of undetermined significance: a new proposal of workup”. Eur. J. Haematol. 91 (4): 356–60. doi:10.1111/ejh.12172. PMID 23859528.

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