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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Motilin receptor

Introduction

Motilin receptor is a G protein-coupled receptor that binds motilin.[1][2] Motilin in turn is an intestinal peptide that stimulates contraction of gut smooth muscle.

References

References

  1. ↑ Depoortere I (2001). “Motilin and motilin receptors: characterization and functional significance”. Verh. K. Acad. Geneeskd. Belg. 63 (6): 511–29. PMID 11813507.
  2. ↑ Yang X, Dong L, Yang H (2006). “[Evidence for the presence of motilin receptor and a study on the mechanism of motilin induced Ca2+ signaling in rat myenteric neurons]”. Sichuan Da Xue Xue Bao Yi Xue Ban (in Chinese). 37 (5): 683–6. PMID 17037727.
Further reading

Further reading

  • Smith RG, Leonard R, Bailey AR, et al. (2001). “Growth hormone secretagogue receptor family members and ligands”. Endocrine. 14 (1): 9–14. doi:10.1385/ENDO:14:1:009. PMID 11322507.
  • McKee KK, Tan CP, Palyha OC, et al. (1998). “Cloning and characterization of two human G protein-coupled receptor genes (GPR38 and GPR39) related to the growth hormone secretagogue and neurotensin receptors”. Genomics. 46 (3): 426–34. doi:10.1006/geno.1997.5069. PMID 9441746.
  • Feighner SD, Tan CP, McKee KK, et al. (1999). “Receptor for motilin identified in the human gastrointestinal system”. Science. 284 (5423): 2184–8. doi:10.1126/science.284.5423.2184. PMID 10381885.
  • Miller P, Roy A, St-Pierre S, et al. (2000). “Motilin receptors in the human antrum”. Am. J. Physiol. Gastrointest. Liver Physiol. 278 (1): G18–23. PMID 10644557.
  • Thielemans L, Depoortere I, Van Assche G, et al. (2001). “Demonstration of a functional motilin receptor in TE671 cells from human cerebellum”. Brain Res. 895 (1–2): 119–28. doi:10.1016/S0006-8993(01)02055-8. PMID 11259768.
  • Coulie B, Matsuura B, Dong M, et al. (2001). “Identification of peptide ligand-binding domains within the human motilin receptor using photoaffinity labeling”. J. Biol. Chem. 276 (38): 35518–22. doi:10.1074/jbc.M104489200. PMID 11461914.
  • Thielemans L, Depoortere I, Vanden Broeck J, Peeters TL (2002). “The motilin pharmacophore in CHO cells expressing the human motilin receptor”. Biochem. Biophys. Res. Commun. 293 (4): 1223–7. doi:10.1016/S0006-291X(02)00356-X. PMID 12054506.
  • Depoortere I, Thijs T, Thielemans L, et al. (2003). “Interaction of the growth hormone-releasing peptides ghrelin and growth hormone-releasing peptide-6 with the motilin receptor in the rabbit gastric antrum”. J. Pharmacol. Exp. Ther. 305 (2): 660–7. doi:10.1124/jpet.102.047563. PMID 12606621.
  • Dunham A, Matthews LH, Burton J, et al. (2004). “The DNA sequence and analysis of human chromosome 13”. Nature. 428 (6982): 522–8. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
  • Matsuura B, Dong M, Naik S, et al. (2006). “Differential contributions of motilin receptor extracellular domains for peptide and non-peptidyl agonist binding and activity”. J. Biol. Chem. 281 (18): 12390–6. doi:10.1074/jbc.M511921200. PMID 16531413.
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