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Health Dictionary

Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Moxalactam

Introduction

Overview

Overview

Latamoxef (or moxalactam) is an oxacephem antibiotic usually grouped with the cephalosporins. In oxacephems such as latamoxef, the sulfur atom of the cephalosporin core is replaced with an oxygen atom.

Latamoxef has been associated with prolonged bleeding time, and several cases of coagulopathy, some fatal, were reported during the 1980s.[1][2] Latamoxef is no longer available in the United States.

References

References

  1. ↑ Weitekamp MR, Aber RC (1983). “Prolonged bleeding times and bleeding diathesis associated with moxalactam administration”. JAMA. 249 (1): 69–71. PMID 6217353.
  2. ↑ Brown RB, Klar J, Lemeshow S, Teres D, Pastides H, Sands M (1986). “Enhanced bleeding with cefoxitin or moxalactam. Statistical analysis within a defined population of 1493 patients”. Arch Intern Med. 146 (11): 2159–64. PMID 3778044.

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]