Multiple myeloma causes
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2] Shyam Patel [3]
Overview
Overview
The causes of multiple myeloma include sporadic mutations, such as TP53 mutation, and inherited predisposition.
Causes
Causes
Common causes
The causes of multiple myeloma include:
- Mutations in the tumor suppressor TP53 (most common)
- Sporadic mutations and genetic predisposition
- Mutations in tumor suppressors or oncogenes
- Chromosomal aberrations such as translocations can trigger the onset of malignancy and allow for uncontrolled plasma cell proliferation.[1]
Less common causes
- Familial causes are less contributory to the development of multiple myeloma compared to sporadic causes.[1]
Causes by Organ System
| Cardiovascular | No underlying causes |
| Chemical/Poisoning | No underlying causes |
| Dental | No underlying causes |
| Dermatologic | No underlying causes |
| Drug Side Effect | No underlying causes |
| Ear Nose Throat | No underlying causes |
| Endocrine | No underlying causes |
| Environmental | No underlying causes |
| Gastroenterologic | No underlying causes |
| Genetic | Mutations in the tumor suppressor TP53, sporadic mutations and genetic predisposition, mutations in tumor suppressors or oncogenes, chromosomal aberrations such as translocations, familial inheritance |
| Hematologic | No underlying causes |
| Iatrogenic | No underlying causes |
| Infectious Disease | No underlying causes |
| Musculoskeletal/Orthopedic | No underlying causes |
| Neurologic | No underlying causes |
| Nutritional/Metabolic | No underlying causes |
| Obstetric/Gynecologic | No underlying causes |
| Oncologic | No underlying causes |
| Ophthalmologic | No underlying causes |
| Overdose/Toxicity | No underlying causes |
| Psychiatric | No underlying causes |
| Pulmonary | No underlying causes |
| Renal/Electrolyte | No underlying causes |
| Rheumatology/Immunology/Allergy | No underlying causes |
| Sexual | No underlying causes |
| Trauma | No underlying causes |
| Urologic | No underlying causes |
| Miscellaneous | No underlying causes |
Causes in Alphabetical Order
List the causes of the multiple myeloma in alphabetical order:
- Chromosomal aberrations
- Familial inheritance
- Mutations in oncogenes
- Mutations in the tumor suppressor TP53
- Mutations in tumor suppressors
- Translocations
References
References
- ↑ 1.0 1.1 Rajkumar SV (2016). “Multiple myeloma: 2016 update on diagnosis, risk-stratification, and management”. Am J Hematol. 91 (7): 719–34. doi:10.1002/ajh.24402. PMC 5291298. PMID 27291302.
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