Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Multiple myeloma causes
Introduction
Overview
Overview
The causes of multiple myeloma include sporadic mutations, such as TP53 mutation, and inherited predisposition.
Causes
Causes
Common causes
The causes of multiple myeloma include:
- Mutations in the tumor suppressor TP53 (most common)
- Sporadic mutations and genetic predisposition
- Mutations in tumor suppressors or oncogenes
- Chromosomal aberrations such as translocations can trigger the onset of malignancy and allow for uncontrolled plasma cell proliferation.[1]
Less common causes
- Familial causes are less contributory to the development of multiple myeloma compared to sporadic causes.[1]
Causes by Organ System
| Cardiovascular | No underlying causes |
| Chemical/Poisoning | No underlying causes |
| Dental | No underlying causes |
| Dermatologic | No underlying causes |
| Drug Side Effect | No underlying causes |
| Ear Nose Throat | No underlying causes |
| Endocrine | No underlying causes |
| Environmental | No underlying causes |
| Gastroenterologic | No underlying causes |
| Genetic | Mutations in the tumor suppressor TP53, sporadic mutations and genetic predisposition, mutations in tumor suppressors or oncogenes, chromosomal aberrations such as translocations, familial inheritance |
| Hematologic | No underlying causes |
| Iatrogenic | No underlying causes |
| Infectious Disease | No underlying causes |
| Musculoskeletal/Orthopedic | No underlying causes |
| Neurologic | No underlying causes |
| Nutritional/Metabolic | No underlying causes |
| Obstetric/Gynecologic | No underlying causes |
| Oncologic | No underlying causes |
| Ophthalmologic | No underlying causes |
| Overdose/Toxicity | No underlying causes |
| Psychiatric | No underlying causes |
| Pulmonary | No underlying causes |
| Renal/Electrolyte | No underlying causes |
| Rheumatology/Immunology/Allergy | No underlying causes |
| Sexual | No underlying causes |
| Trauma | No underlying causes |
| Urologic | No underlying causes |
| Miscellaneous | No underlying causes |
Causes in Alphabetical Order
List the causes of the multiple myeloma in alphabetical order:
- Chromosomal aberrations
- Familial inheritance
- Mutations in oncogenes
- Mutations in the tumor suppressor TP53
- Mutations in tumor suppressors
- Translocations
References
References
- ↑ 1.0 1.1 Rajkumar SV (2016). “Multiple myeloma: 2016 update on diagnosis, risk-stratification, and management”. Am J Hematol. 91 (7): 719–34. doi:10.1002/ajh.24402. PMC 5291298. PMID 27291302.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2] Shyam Patel [3]