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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Mural cell

Introduction

The term mural cell refers generally to vascular smooth muscle cells and pericytes, both involved in the formation of normal vasculature and responsive to vascular endothelial growth factor (VEGF).[1] The weakness and disorganization of tumor vasculature is partly due to the inability of tumors to recruit properly organized mural cells.[2]

References

  1. ↑ Fujimoto, Akihisa, Onodera, Hisashi, Mori, Akira, Isobe, Naoki, Yasuda, Seiichi, Oe, Hideaki, Yonenaga, Yoshikuni, Tachibana, Tsuyoshi & Imamura, Masayuki (2004) Vascular endothelial growth factor reduces mural cell coverage of endothelial cells and induces sprouting rather than luminal division in an HT1080 tumour angiogenesis model. International Journal of Experimental Pathology 85 (6), 355-364.
  2. ↑ Abramsson A, Berlin O, Papayan H, Paulin D, Shani M, Betsholtz C. (2002). Analysis of Mural Cell Recruitment to Tumor Vessels. Circulation 105:112.