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Reliable, easy-to-read patient information on common medical conditions β€” written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Muscle weakness and Myoglobinuria

Introduction

Differential Diagnosis of Muscle weakness and Myoglobinuria

Differential Diagnosis of Muscle weakness and Myoglobinuria

Organ system Disease Symptoms History Physical

Examination

Diagnosis
Age of onset Muscle weakness Fever Myalgia Contractures Gait abnormality Neuropathy Atrophy Stiffness Myoglobinuria Other features Laboratory Findings Creatine Kinase Muscle Biopsy Electromyogram
Medicationβˆ’induced Statins[1] 60+ Proximal βˆ’ + βˆ’ βˆ’ βˆ’ βˆ’ βˆ’ βˆ’/+(Rhabdomyolysis)
  • N/A
  • Positive h/o medications
  • H/o other medication use
  • ↑↑ Liver enzymes
  • ↑↑
  • Necrosis
  • Degeneration, and regeneration of fibers
  • Phagocytic infiltration
  • Normal
Endocrine Hyperaldosteronism with myopathy[2] 50 Proximal
&
distal 		βˆ’ βˆ’ βˆ’ βˆ’ βˆ’ βˆ’ βˆ’ +

Rhabdomyolysis

  • Normal
  • Normal
  • Normal
Hyperthyroidism[3] 40 Proximal βˆ’ βˆ’ βˆ’ βˆ’ βˆ’ + + +
  • ↑↑
  • Non specific
Hypothyroidism[4] 55 Proximal βˆ’ + + βˆ’ βˆ’ + + + Rhabdomyolysis
  • ↑↑
  • NonspecificΒ 
  • Normal
Infectious Influenza[5] Variable Proximal and Distal + + βˆ’ + βˆ’ βˆ’ βˆ’ +
  • Cold weather
  • H/o Ill contacts
  • Muscle weakness, tenderness, and swelling.
  • ↑↑ Liver enzymes
  • Positive PCR
  • ↑↑
  • N/A
  • N/A
References

References

  1. ↑ Tomaszewski M, StΔ™pieΕ„ KM, Tomaszewska J, Czuczwar SJ (2011). “Statin-induced myopathies”. Pharmacol Rep. 63 (4): 859–66. PMIDΒ 22001973.
  2. ↑ Sambrook MA, Heron JR, Aber GM (April 1972). “Myopathy in association with primary hyperaldosteronism”. J. Neurol. Neurosurg. Psychiatry. 35 (2): 202–7. PMCΒ 494037. PMIDΒ 5037033.
  3. ↑ Li Q, Liu Y, Zhang Q, Tian H, Li J, Li S (July 2017). “Myopathy in hyperthyroidism as a consequence of rapid reduction of thyroid hormone: A case report”. Medicine (Baltimore). 96 (30): e7591. doi:10.1097/MD.0000000000007591. PMCΒ 5627834. PMIDΒ 28746208.
  4. ↑ Khaleeli AA, Griffith DG, Edwards RH (September 1983). “The clinical presentation of hypothyroid myopathy and its relationship to abnormalities in structure and function of skeletal muscle”. Clin. Endocrinol. (Oxf). 19 (3): 365–76. PMIDΒ 6627693.
  5. ↑ Bove KE, Hilton PK, Partin J, Farrell MK (1983). “Morphology of acute myopathy associated with influenza B infection”. Pediatr Pathol. 1 (1): 51–66. PMIDΒ 6687269.

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Iqra Qamar M.D.[2]