Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Myelodysplastic syndrome laboratory findings
Introduction
Overview
Overview
Laboratory findings consistent with the diagnosis of myelodysplastic syndrome include abnormal complete blood count, peripheral blood smear, cytogenetic analysis, and immunohistochemistry.[1][2][3][4][5][6][7][8]
Laboratory Findings
Laboratory Findings
Laboratory findings consistent with the diagnosis of myelodysplastic syndrome include abnormal complete blood count, peripheral blood smear, cytogenetic analysis, immunohistochemistry, and bone marrow biopsy.[1]
Complete Blood Count
On complete blood count, characteristic findings of myelodysplastic syndrome include:[1]
Peripheral Blood Smear
On peripheral blood smear, characteristic findings of myelodysplastic syndrome include:[2][3][4][5]
- Macro-ovalocytes
- Basophilic stippling
- Howell-Jolly body
- Acquired or pseudo-Pelger-Huët anomaly
Cytogenetic Analysis
On cytogenetic analysis, characteristic findings of myelodysplastic syndrome include:[6][7]
- Deletions within the long arm of chromosome 5
- Deletions within the short arm of chromosome 17
- Monosomy 7
- Monosomy 8
References
References
- ↑ 1.0 1.1 1.2 Tests to examine and diagnose myelodysplastic syndromes. National Cancer Institute 2015. http://www.cancer.gov/types/myeloproliferative/patient/myelodysplastic-treatment-pdq. Accessed on December 14, 2015
- ↑ 2.0 2.1 Causes of macrocytosis. Wikipedia (2015). https://en.wikipedia.org/wiki/Macrocytosis. Accessed on December 14, 2015
- ↑ 3.0 3.1 Basophilic stippling. Wikipedia (2015). https://en.wikipedia.org/wiki/Basophilic_stippling. Accessed on December 14, 2015
- ↑ 4.0 4.1 Causes of Howell-Jolly body. Wikipedia (2015). https://en.wikipedia.org/wiki/Howell%E2%80%93Jolly_body. Accessed on December 14, 2015
- ↑ 5.0 5.1 Acquired or pseudo-Pelger-Huët anomaly. Wikipedia (2015). https://en.wikipedia.org/wiki/Pelger%E2%80%93Huet_anomaly. Accessed on December 14, 2015
- ↑ 6.0 6.1 Cytogenetics of myelodysplastic syndromes. Librepathology (2015). http://librepathology.org/wiki/index.php/Myelodysplastic_syndromes. Accessed on December 8, 2015
- ↑ 7.0 7.1 Haase, Detlef (2008). “Cytogenetic features in myelodysplastic syndromes”. Annals of Hematology. 87 (7): 515–526. doi:10.1007/s00277-008-0483-y. ISSN 0939-5555.
- ↑ Tricot, G.; Wolf-Peeters, C. De; Hendrickx, B.; Verwilghen, R. L. (1984). “Bone marrow histology in myelodysplastic syndromes”. British Journal of Haematology. 57 (3): 423–430. doi:10.1111/j.1365-2141.1984.tb02916.x. ISSN 0007-1048.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Nawal Muazam M.D.[2]