Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Myelofibrosis screening
Introduction
Overview
Overview
There is insufficient evidence to recommend routine screening for myelofibrosis and there is no screening test currently available for the disease. Routine blood work can be used to check the blood cell counts which can further warrant a bone marrow biopsy.
Screening
Screening
- There is insufficient evidence to recommend routine screening for myelofibrosis.
- Blood cell counts can be determined and monitored for any irregularity which can then further warrant a bone marrow biopsy.
- According to 2008 World Health Organization (WHO) classification of myeloproliferative neoplasms, JAK2V617F is the most prevalent mutation with approximately 60% of the primary myelofibrosis (PMF) patients carrying this mutation. This trend is followed in frequency by the mutations in myeloproliferative leukemia virus (MPL) and calreticulin (CALR) genes.[1][2][3]
- Patients can be screened for the above mentioned mutations based on this data.
References
References
- ↑ Barbui T, Thiele J, Gisslinger H, Kvasnicka HM, Vannucchi AM, Guglielmelli P, Orazi A, Tefferi A (February 2018). “The 2016 WHO classification and diagnostic criteria for myeloproliferative neoplasms: document summary and in-depth discussion”. Blood Cancer J. 8 (2): 15. doi:10.1038/s41408-018-0054-y. PMC 5807384. PMID 29426921.
- ↑ Kralovics R, Passamonti F, Buser AS, Teo SS, Tiedt R, Passweg JR, Tichelli A, Cazzola M, Skoda RC (April 2005). “A gain-of-function mutation of JAK2 in myeloproliferative disorders”. N. Engl. J. Med. 352 (17): 1779–90. doi:10.1056/NEJMoa051113. PMID 15858187.
- ↑ Vardiman JW, Thiele J, Arber DA, Brunning RD, Borowitz MJ, Porwit A, Harris NL, Le Beau MM, Hellström-Lindberg E, Tefferi A, Bloomfield CD (July 2009). “The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes”. Blood. 114 (5): 937–51. doi:10.1182/blood-2009-03-209262. PMID 19357394.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]Sabawoon Mirwais, M.B.B.S, M.D.[3]