Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Myocardin
Introduction
Myocardin is a protein that in humans is encoded by the MYOCD gene.[1][2][3]
Myocardin is a smooth muscle and cardiac muscle-specific transcriptional coactivator of serum response factor. When expressed ectopically in nonmuscle cells, myocardin can induce smooth muscle differentiation by its association with serum response factor (SRF; MIM 600589).[supplied by OMIM][3]
References
References
- ↑ Wang D, Chang PS, Wang Z, Sutherland L, Richardson JA, Small E, Krieg PA, Olson EN (Jul 2001). “Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor”. Cell. 105 (7): 851–62. doi:10.1016/S0092-8674(01)00404-4. PMID 11439182.
- ↑ Wang DZ, Li S, Hockemeyer D, Sutherland L, Wang Z, Schratt G, Richardson JA, Nordheim A, Olson EN (Nov 2002). “Potentiation of serum response factor activity by a family of myocardin-related transcription factors”. Proc Natl Acad Sci U S A. 99 (23): 14855–60. doi:10.1073/pnas.222561499. PMC 137508. PMID 12397177.
- ↑ 3.0 3.1 “Entrez Gene: MYOCD myocardin”.
Further reading
Further reading
- Du KL, Ip HS, Li J, et al. (2003). “Myocardin is a critical serum response factor cofactor in the transcriptional program regulating smooth muscle cell differentiation”. Mol. Cell. Biol. 23 (7): 2425–37. doi:10.1128/MCB.23.7.2425-2437.2003. PMC 150745. PMID 12640126.
- Wang Z, Wang DZ, Pipes GC, Olson EN (2003). “Myocardin is a master regulator of smooth muscle gene expression”. Proc. Natl. Acad. Sci. U.S.A. 100 (12): 7129–34. doi:10.1073/pnas.1232341100. PMC 165841. PMID 12756293.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). “Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Du KL, Chen M, Li J, et al. (2004). “Megakaryoblastic leukemia factor-1 transduces cytoskeletal signals and induces smooth muscle cell differentiation from undifferentiated embryonic stem cells”. J. Biol. Chem. 279 (17): 17578–86. doi:10.1074/jbc.M400961200. PMID 14970199.
- Wang Z, Wang DZ, Hockemeyer D, et al. (2004). “Myocardin and ternary complex factors compete for SRF to control smooth muscle gene expression”. Nature. 428 (6979): 185–9. doi:10.1038/nature02382. PMID 15014501.
- van Tuyn J, Knaän-Shanzer S, van de Watering MJ, et al. (2006). “Activation of cardiac and smooth muscle-specific genes in primary human cells after forced expression of human myocardin”. Cardiovasc. Res. 67 (2): 245–55. doi:10.1016/j.cardiores.2005.04.013. PMID 15907818.
- Liu ZP, Wang Z, Yanagisawa H, Olson EN (2005). “Phenotypic modulation of smooth muscle cells through interaction of Foxo4 and myocardin”. Dev. Cell. 9 (2): 261–70. doi:10.1016/j.devcel.2005.05.017. PMID 16054032.
- Doi H, Iso T, Yamazaki M, et al. (2006). “HERP1 inhibits myocardin-induced vascular smooth muscle cell differentiation by interfering with SRF binding to CArG box”. Arterioscler. Thromb. Vasc. Biol. 25 (11): 2328–34. doi:10.1161/01.ATV.0000185829.47163.32. PMID 16151017.
- Zody MC, Garber M, Adams DJ, et al. (2006). “DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage”. Nature. 440 (7087): 1045–9. doi:10.1038/nature04689. PMC 2610434. PMID 16625196.
- Chow N, Bell RD, Deane R, et al. (2007). “Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer’s phenotype”. Proc. Natl. Acad. Sci. U.S.A. 104 (3): 823–8. doi:10.1073/pnas.0608251104. PMC 1783398. PMID 17215356.
- Milyavsky M, Shats I, Cholostoy A, et al. (2007). “Inactivation of myocardin and p16 during malignant transformation contributes to a differentiation defect”. Cancer Cell. 11 (2): 133–46. doi:10.1016/j.ccr.2006.11.022. PMID 17292825.
- Li HJ, Haque Z, Lu Q, et al. (2007). “Steroid receptor coactivator 3 is a coactivator for myocardin, the regulator of smooth muscle transcription and differentiation”. Proc. Natl. Acad. Sci. U.S.A. 104 (10): 4065–70. doi:10.1073/pnas.0611639104. PMC 1820709. PMID 17360478.
- Pijnappels DA, van Tuyn J, de Vries AA, et al. (2007). “Resynchronization of separated rat cardiomyocyte fields with genetically modified human ventricular scar fibroblasts”. Circulation. 116 (18): 2018–28. doi:10.1161/CIRCULATIONAHA.107.712935. PMID 17938287.