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Myod family inhibitor domain containing
Introduction
MyoD family inhibitor domain containing is a protein that in humans is encoded by the MDFIC gene. [1]
Function
Function
This gene product is a member of a family of proteins characterized by a specific cysteine-rich C-terminal domain, which is involved in transcriptional regulation of viral genome expression. Alternative translation initiation from an upstream non-AUG (GUG), and an in-frame, downstream AUG codon, results in the production of two isoforms, p40 and p32, respectively, which have different subcellular localization; p32 is mainly found in the cytoplasm, whereas p40 is targeted to the nucleolus. Both isoforms have transcriptional regulatory activity that is attributable to the cysteine-rich C-terminal domain. Alternative splicing results in multiple transcript variants.
References
References
- ↑ “Entrez Gene: MyoD family inhibitor domain containing”. Retrieved 2016-02-09.
Further reading
Further reading
This article incorporates text from the United States National Library of Medicine, which is in the public domain.