• There is no single diagnostic study of choice for the diagnosis of [[myoglobinuria], but myoglobinuria can be diagnosed based on creatine kinase (CK) levels to assess for rhabdomyolysis.
• Myoglobin is first enzyme to increase in cases of rhabdomyolysis, but it returns to normal levels within up to 24 hours after the onset of symptoms, because it is rapidly cleared by the kidneys. Serum CK levels remain elevated after serum and urine test results for myoglobin have become negative. CK levels normally peak (1000 U/L) around 3 days after the onset of symptoms, and remain elevated for several days. ^[1]

The following result of creatine kinase(CK) is confirmatory of myoglobinuria, caused my rhabdomyolysis:

• CK 1000 U/L

The creatine kinase levels should be performed when:

• The patient presented with symptoms/signs of myalgia, muscle weakness, and dark urine as the first step of diagnosis.
• A positive creatine kinase level is detected in the patient, to confirm the diagnosis.

• There are no established criteria for the diagnosis of [disease name].