Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Myxoma historical perspective
Introduction
Overview
Overview
Cardiac myxoma was first described in 1845. In 1951, Prichard described a kind of microscopic endocardial structure of the atrial septum, which was suggested to be associated with cardiac myxoma. Clarence Crafoord, a Swedish cardiovascular surgeon successfully removed a cardiac myxoma for the first time in 1954. Before 1951, cardiac myxoma diagnosis was made only at post-mortem examination.
Historical perspective
Historical perspective
- In 1951, Prichard described a kind of microscopic endocardial structure of the atrial septum, which was suggested to be related to cardiac myxoma.[2]
- In 1951, intracardiac myxoma was recognized by angiography for the first time. Before 1951, cardiac myxoma diagnosis was made only at autopsy.[3]
- In 1959, the first M-mode echocardiogram was used to diagnose a left atrial myxoma.[4]
- In 2000, gene mutation PRKAR1A was first identified in the pathogenesis of cardiac myxoma syndromes, such as; LAMB (lentigines, atrial myxoma, mucocutaneous myxomas and blue nevi), NAME (nevi, atrial myxoma, mucinosis of the skin, and endocrine overactivity), and Carney complex (myxomas, spotty skin pigmentation and endocrine overactivity).[5][6].
Landmark Events in the Development of Treatment Strategies
- In 1954, Clarence Crafoord (1899 – 1984), a Swedish cardiovascular surgeon, successfully removed a cardiac myxoma for the first time. This case also represents the first extirpation of a cardiac tumor on cardiopulmonary support.[7][8]
References
References
- ↑ King TW. On simple vascular growths in the left auricle of the heart. Lancet 1845; 2:428-9
- ↑ Amano J, Kono T, Wada Y, Zhang T, Koide N, Fujimori M, Ito K (2003). “Cardiac myxoma: its origin and tumor characteristics”. Ann Thorac Cardiovasc Surg. 9 (4): 215–21. PMID 13129418.
- ↑ Guhathakurta S, Riordan JP (2000). “Surgical treatment of right atrial myxoma”. Tex Heart Inst J. 27 (1): 61–3. PMC 101023. PMID 10830633.
- ↑ Pinede L, Duhaut P, Loire R (2001). “Clinical presentation of left atrial cardiac myxoma. A series of 112 consecutive cases”. Medicine (Baltimore). 80 (3): 159–72. PMID 11388092.
- ↑ Carney JA, Hruska LS, Beauchamp GD, Gordon H (1986). “Dominant inheritance of the complex of myxomas, spotty pigmentation, and endocrine overactivity”. Mayo Clin. Proc. 61 (3): 165–72. PMID 3945116.
- ↑ Mabuchi T, Shimizu M, Ino H, Yamguchi M, Terai H, Fujino N, Nagata M, Sakata K, Inoue M, Yoneda T, Mabuchi H (2005). “PRKAR1A gene mutation in patients with cardiac myxoma”. Int. J. Cardiol. 102 (2): 273–7. doi:10.1016/j.ijcard.2004.05.053. PMID 15982496.
- ↑ Chitwood WR (1992). “Clarence Crafoord and the first successful resection of a cardiac myxoma”. Ann. Thorac. Surg. 54 (5): 997–8. PMID 1417305.
- ↑ Chitwood WR (November 1992). “Clarence Crafoord and the first successful resection of a cardiac myxoma”. Ann. Thorac. Surg. 54 (5): 997–8. doi:10.1016/0003-4975(92)90676-u. PMID 1417305.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sogand Goudarzi, MD [2] Maria Fernanda Villarreal, M.D. [3]