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N-acetyl-alpha-D-glucosaminidase

Introduction

Alpha-N-acetylglucosaminidase (EC 3.2.1.50, alpha-acetylglucosaminidase, N-acetyl-alpha-D-glucosaminidase, N-acetyl-alpha-glucosaminidase, alpha-D-2-acetamido-2-deoxyglucosidase) is a protein associated with Sanfilippo syndrome. It is an enzyme with systematic name alpha-N-acetyl-D-glucosaminide N-acetylglucosaminohydrolase.[1][2][3][4] This enzyme catalyses the following chemical reaction

Hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides

This enzyme hydrolyses UDP-N-acetylglucosamine.

References

References

  1. ↑ von Figura K (November 1977). “Human alpha-N-acetylglucosaminidase. 1. Purification and properties”. European Journal of Biochemistry. 80 (2): 523–33. doi:10.1111/j.1432-1033.1977.tb11908.x. PMID 411658.
  2. ↑ von Figura K (November 1977). “Human alpha-n-acetylglucosaminidase. 2. Activity towards natural substrates and multiple recognition forms”. European Journal of Biochemistry. 80 (2): 535–42. doi:10.1111/j.1432-1033.1977.tb11909.x. PMID 923593.
  3. ↑ Weissmann B, Rowin G, Marshall J, Friederici D (January 1967). “Mammalian alpha-acetylglucosaminidase. Enzymic properties, tissue distribution, and intracellular localization”. Biochemistry. 6 (1): 207–14. doi:10.1021/bi00853a033. PMID 4291567.
  4. ↑ Werries E, Wollek E, Gottschalk A, Buddecke E (October 1969). “Separation of N-acetyl-alpha-glucosaminidase and N-acetyl-alpha-galactosaminidase from ox spleen. Cleavage of the O-glycosidic linkage between carbohydrate and polypeptide in ovine and bovine submaxillary glycoprotein by N-acetyl-alpha-galactosaminidase”. European Journal of Biochemistry. 10 (3): 445–9. doi:10.1111/j.1432-1033.1969.tb00709.x. PMID 5348072.
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